Design of oral intestinal-specific alginate-vitexin nanoparticulate system to modulate blood glucose level of diabetic rats

Shaedi, Nafisha; Naharudin, Idanawati; Choo, Chee Yan; Wong, Tin Wui

doi:10.1016/j.carbpol.2020.117312

Cited by 15 publications

(10 citation statements)

References 45 publications

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“…A schematic presentation of alginate-based material preparation for cancer therapy is shown in Figure 4 . Shaedi et al designed an oral gut specific alginate nano-system for vitexin [ 115 ]. In the study, stearic acid was used to make the matrix hydrophobic, which promotes the early release of vitexin, and the nanoparticles are compacted with polyethylene glycol (PEG3000, 10,000 and 20,000).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…In the study, stearic acid was used to make the matrix hydrophobic, which promotes the early release of vitexin, and the nanoparticles are compacted with polyethylene glycol (PEG3000, 10,000 and 20,000). The results showed that compacting the nanoparticles with PEG significantly reduced the release of vitexin in the gastric region, while the release of vitexin in the intestinal tract increased by the nanoparticles loaded with stearic acid [ 115 ]. The use of PEG-10,000 during the compaction process will lead to PEG-nanoparticle interactions, thereby inhibiting the initial release of vitexin.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

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Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

2021

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Alginates are naturally occurring polysaccharides extracted from brown marine algae and bacteria. Being biocompatible, biodegradable, non-toxic and easy to gel, alginates can be processed into various forms, such as hydrogels, microspheres, fibers and sponges, and have been widely applied in biomedical field. The present review provides an overview of the properties and processing methods of alginates, as well as their applications in wound healing, tissue repair and drug delivery in recent years.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

2021

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“…1(a)). 10,12,22 The mPEG-g-CTS/ALG nanoparticles showed characteristic peaks at 2800-3000 cm −1 (C H stretching) and 1740 cm −1 (C O of the ester bond) belonging to mPEG-g-CTS 33 and oil. 40 They also showed peaks at 1625 cm −1 (asymmetric COO − ) and 1409 cm −1 (symmetric COO − ) that belong to mPEG-g-CTS/ALG polyelectrolyte complexes 33 (Fig.…”

Section: Chemical Structurementioning

confidence: 99%

“…catalase 17 and nifedipine, 19 increasing their bioavailability and preventing unnecessary interactions with other substances. Crude extract 20,21 and pure vitexin forms 16,22 have previously been encapsulated in various biopolymer shells, including a mixture of κ-carrageenan and sodium carboxymethyl cellulose 20 ; alginate (ALG), ALG-stearic acid and ALG-stearic acid conjugate nanoparticles 22 ; chitosantripolyphosphate particles with and without an ALG-calcium chloride matrix coating 21 ; and bilayer nanoparticles assembled from soybean peptides coated with N-trimethylchitosan coupled to the goblet cell targeting peptide CSKSSDYQC 16 through different methods, including spray drying 20,22 and ionotropic gelation. 14,21 Chitosan and ALG are good biopolymer candidates for shells or particulate carriers due to their nontoxicity, biocompatibility, biodegradability, natural abundance and ability to form particles through polyelectrolyte complexation without toxic crosslinkers.…”

Section: Introductionmentioning

confidence: 99%

Vitexin‐loaded poly(ethylene glycol) methyl ether‐grafted chitosan/alginate nanoparticles: preparation, physicochemical properties and in vitro release behaviors

Yoksan,

Towongphaichayonte

2023

J Sci Food Agric

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BACKGROUNDVitexin, a flavonoid in various foods and medicinal plants, has potential clinical, therapeutic, and food applications due to its bioactive properties and beneficial health effects. However, its poor water solubility causes low oral bioavailability and poor absorption in the gastrointestinal tract, limiting its practical applications. Encapsulation is an efficient approach to overcome these limitations. This study demonstrates the encapsulation of vitexin into poly(ethylene glycol) methyl ether‐grafted chitosan (mPEG‐g‐CTS)/alginate (ALG) polyelectrolyte complex nanoparticles.RESULTSThe vitexin‐loaded mPEG‐g‐CTS/ALG nanoparticles were characterized by Fourier‐transform infrared spectroscopy, ultraviolet‐visible spectroscopy, and X‐ray diffraction. The vitexin‐loaded mPEG‐g‐CTS/ALG nanoparticles had a spherical shape, 50–200 nm diameter, and negatively charged surface (−27 to −38 mV). They possessed a loading capacity of 4%−60%, encapsulation efficiency of 50%−100%, and antioxidant activity (30%−52% 2,2‐diphenyl‐1‐picrylhydrazyl decoloration) when their initial vitexin content was 0.02–0.64 g/g polymers. Successful vitexin loading into mPEG‐g‐CTS/ALG nanoparticles was also indirectly confirmed by the enhanced thermal stability of both polymers and the residual soybean oil used in the emulsion preparation step and delayed oxidative degradation of the residual soybean oil. Vitexin's in vitro release from the mPEG‐g‐CTS/ALG nanoparticles was very fast in phosphate buffer at pH 11, followed by pH 7, and very slow in acetate buffer at pH 3. The gastrointestinal digestion of vitexin increased by encapsulating into mPEG‐g‐CTS/ALG nanoparticles.CONCLUSIONSThe vitexin‐loaded mPEG‐g‐CTS/ALG nanoparticles were successfully fabricated using a two‐step process of oil‐in‐water emulsion and ionic gelation without pungent odor acids and other crosslinkers. The obtained nanoparticles are suitable for oral intestinal‐specific delivery systems.This article is protected by copyright. All rights reserved.

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“…Unfortunately, extremely low water dissolubility and intestinal first-pass effects significantly with low bioavailability prevent Vi applications [17]. So far, several drug nano-delivery systems (NDDS) have been prepared to improve the aqueous solubility of Vi, viz., β-cyclodextrin inclusion complexes [18], alginate nanoparticles [19] and Vi nanoparticles [20]. However, micelle delivery system of Vi has not been reported to improve bioavailability and anti-osteoporotic effect.…”

Section: Introductionmentioning

confidence: 99%

Vitexin loaded mixed polymeric micelles: preparation, optimization, evaluation and anti-osteoporotic effect

Zhang

Xia

et al. 2023

Biomed. Mater.

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Purpose In this regard, we developed vitexin (Vi)-loaded D-ɑ-tocopherol polyethylene glycol succinate, polyvinylpyrrolidone K30 and sodium cholate mixed micelles (Vi-MMs) mainly for improving oral bioavailability and enhancing anti-osteoporotic effect of Vi. Methods Thin layer dispersion method was employed to prepare Vi-MMs, and then the optimal prescription was optimized by the orthogonal design-response surface method, wherein encapsulation efficiency (EE) was used as optimizing index. The physical properties of Vi-MMs such as appearance morphology, particle size, and zeta potential were also characterized. We further analyzed the in-vitro release of Vi and Vi-MMs in three media and investigated the pharmacokinetics of Vi and Vi-MMs in rats. Anti-osteoporotic activity of Vi and Vi-MMs was assessed by establishing a zebrafish osteoporosis model with prednisone.Results Drug loading, encapsulation efficiency, particle size and zeta potential of the optimized Vi-MMs were 8.58 ± 0.13%, 93.86 ± 1.79%, 20.41 ± 0.64 nm and -10 ± 0.56 mV, respectively. The optimized Vi-MMs were shaped spherically as exhibited by transmission electron microscopic technique, with evident core shell nano-structure, well dispersed. In all three media, the release rate of Vi-MMs was significantly higher than that of free Vi. The oral bioavailability of Vi-MMs was increased by 5.6-fold compared to free Vi. In addition, alleviation of prednisone induced osteoporosis in zebrafish by Vi-MMs further demonstrated good anti-osteoporotic effect.

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Design of oral intestinal-specific alginate-vitexin nanoparticulate system to modulate blood glucose level of diabetic rats

Cited by 15 publications

References 45 publications

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

Vitexin‐loaded poly(ethylene glycol) methyl ether‐grafted chitosan/alginate nanoparticles: preparation, physicochemical properties and in vitro release behaviors

Vitexin loaded mixed polymeric micelles: preparation, optimization, evaluation and anti-osteoporotic effect

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