Design of peptidomimetic farnesyltransferase inhibitors as anticancer agents

Ro, Seonggu; Lee, Jinho; Baek, Seon-Goan; Cho, Hae Yeon; Kim, Jong Hyun; Shin, Dayeon; Jung, Woo-Hwan; Park, Chihyo; Lee, Hyun Il; Shin, Yu Seung; Ahn, In-Ae; Yoo, Jung-Kwon; Park, Kiwon; Moon, Kyungduk; Chung, Hyun-Ho; Koh, Jong-Sung

doi:10.1007/0-306-46881-6_183

Cited by 2 publications

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“…The approach facilitated the study of protein-protein interactions where multiple proteins are involved and demonstrated high-throughput monitoring of affinity-tagged proteins in expression and purification processes (Ro et al, 2005). Moreover, they chose the Human Papilloma Virus E6 protein with its binding proteins, the ligase E6AP and the tumor suppressor p53, as a model study to investigate the triple protein interaction (E6/E6AP/p53) that takes place during the viral A c c e p t e d M a n u s c r i p t infection (Ro et al, 2006). The complex formation induces a degradation of p53 and, consequently causes the transformation of normal cells into malignant cells and work in this area supports the development of new anticancer drugs against HPV-related cervical cancer.…”

Section: Shortly After Its Introduction Bymentioning

confidence: 99%

Surface Plasmon Resonance Imaging for Affinity-Based Biosensors

Scarano¹,

Scuffi²,

Mascini³

et al. 2009

Lecture Notes in Electrical Engineering

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SPR imaging (SPRi) is at the forefront of optical label-free and real-time detection. It offers the possibility of monitoring hundreds of biological interactions simultaneously and from the binding profiles, allows the estimation of the kinetic parameters of the interactions between the immobilised probes and the ligands in solution. We review the current state of development of SPRi technology and its application. Commercially available SPRi instruments are covered. Attention is also given to surface chemistries for biochip functionalisation and suitable approaches to improve sensitivity.

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Section: Shortly After Its Introduction Bymentioning

confidence: 99%

Surface Plasmon Resonance Imaging for Affinity-Based Biosensors

Scarano¹,

Scuffi²,

Mascini³

et al. 2009

Lecture Notes in Electrical Engineering

View full text Add to dashboard Cite

show abstract

“…The approach facilitated the study of protein-protein interactions where multiple proteins are involved and demonstrated high-throughput monitoring of affinity-tagged proteins in expression and purification processes (Ro et al, 2005). Moreover, they chose the Human Papilloma Virus E6 protein with its binding proteins, the ligase E6AP and the tumor suppressor p53, as a model study to investigate the triple protein interaction (E6/E6AP/p53) that takes place during the viral infection (Ro et al, 2006). The complex formation induces a degradation of p53 and, consequently causes the transformation of normal cells into malignant cells and work in this area supports the development of new anticancer drugs against HPV-related cervical cancer.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Surface plasmon resonance imaging for affinity-based biosensors

Scarano

Mascini

Turner

et al. 2010

Biosensors and Bioelectronics

395

172

View full text Add to dashboard Cite

SPR imaging (SPRi) is at the forefront of optical label-free and real-time detection. It offers the possibility of monitoring hundreds of biological interactions simultaneously and from the binding profiles, allows the estimation of the kinetic parameters of the interactions between the immobilised probes and the ligands in solution. We review the current state of development of SPRi technology and its application including commercially available SPRi instruments. Attention is also given to surface chemistries for biochip functionalisation and suitable approaches to improve sensitivity.

show abstract

Design of peptidomimetic farnesyltransferase inhibitors as anticancer agents

Cited by 2 publications

References 0 publications

Surface Plasmon Resonance Imaging for Affinity-Based Biosensors

Surface Plasmon Resonance Imaging for Affinity-Based Biosensors

Surface plasmon resonance imaging for affinity-based biosensors

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