Design of polysaccharidic nano-in-micro soft agglomerates as primary oral drug delivery vehicle for colon-specific targeting

Musa, Nafisah; Wong, Tin Wui

doi:10.1016/j.carbpol.2020.116673

Cited by 19 publications

(5 citation statements)

References 40 publications

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“…Presently, numerous studies have indicated that self-assembly or encapsulation of active components in nanoparticles can effectively protect them from premature degradation in the stomach and small intestine, leading to enhanced stability. 45,46 These findings align with the results obtained in this study.…”

Section: Aps Improve the Biopharmaceutical Properties Of Flavonoids A...supporting

confidence: 91%

A Multi-Component Nano-Co-Delivery System Utilizing Astragalus Polysaccharides as Carriers for Improving Biopharmaceutical Properties of Astragalus Flavonoids

Yang,

Wu,

Zeng

et al. 2023

IJN

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Enhancing the dissolution, permeation and absorption of active components with low solubility and poor permeability is crucial for maximizing therapeutic efficacy and optimizing functionality. The objective of this study is to investigate the potential of natural polysaccharides as carriers to improve the biopharmaceutical properties of active components. Methods: In this study, we employed four representative flavonoids in Astragali Radix, namely Calycosin-7-O-β-D-glucoside (CAG), Ononin (ON), Calycosin (CA) and Formononetin (FMN), as a demonstration to evaluate the potential of Astragalus polysaccharides (APS) as carriers to improve the biopharmaceutical properties, sush as solubility, permeability, and absorption in vivo. In addition, the microstructure of the flavonoids-APS complexes was characterized, and the interaction mechanism between APS and flavonoids was investigated using multispectral technique and molecular dynamics simulation. Results:The results showed that APS can self-assemble into aggregates with a porous structure and large surface area in aqueous solutions. These aggregates can be loaded with flavonoids through weak intermolecular interactions, such as hydrogen bonding, thereby improving their gastrointestinal stability, solubility, permeability and absorption in vivo. Conclusion:We discovered the self-assembly properties of APS and its potential as carriers. Compared with introducing external excipients, the utilization of natural polysaccharides in plants as carriers may have a unique advantage in enhancing dissolution, permeation and absorption.

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Section: Aps Improve the Biopharmaceutical Properties Of Flavonoids A...supporting

confidence: 91%

A Multi-Component Nano-Co-Delivery System Utilizing Astragalus Polysaccharides as Carriers for Improving Biopharmaceutical Properties of Astragalus Flavonoids

Yang,

Wu,

Zeng

et al. 2023

IJN

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“…Musa et al loaded NPs in the form of soft agglomerates, which reduced premature drug release. 105 The in vitro release experiment showed that the 5-FU-loaded NPs sustained drug release via their response to the intracapsular sodium alginate coat, indicating their potential to achieve colon-specific targeting by oral intake. The epithelium of the large intestine is covered by a bilayered mucus structure comprising water, electrolytes, lipids, and glycoproteins.…”

Section: Design Of Colorectal-targeted Lipid Nanoparticlesmentioning

confidence: 95%

Research Advances of Lipid Nanoparticles in the Treatment of Colorectal Cancer

Zhang,

Ali,

Wang

2024

IJN

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“…CS is the only natural polysaccharide with cationic properties and has been widely used in the biomedical, pharmaceutical, cosmetic, and food industries. CS-based vehicles have been recognized as effective drug delivery systems for enhancing the oral bioavailability of drugs, phytochemicals and bioactive macromolecules including proteins, peptides and polysaccharides [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. So far, many CS-based drug delivery systems such as hydrogels, microparticles, and nanoparticles (NPs) have been developed [ 20 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…CS-based vehicles have been recognized as effective drug delivery systems for enhancing the oral bioavailability of drugs, phytochemicals and bioactive macromolecules including proteins, peptides and polysaccharides [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. So far, many CS-based drug delivery systems such as hydrogels, microparticles, and nanoparticles (NPs) have been developed [ 20 , 27 , 28 ]. Among them, CS NPs are the most promising orally administered dosage forms, as they show great potential to enhance oral bioavailability [ 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Nanoparticles Prepared from Chitosan and Casein for Delivery of Bioactive Polysaccharides

et al. 2022

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Ophiopogon japonicus polysaccharides (OJPs) have great anti-inflammation and immunomodulatory abilities. However, the low bioavailability of OJPs reduces its applicability in the biomedical and pharmaceutical fields. Chitosan (CS) has excellent mucoadhesive properties and absorption-enhancing ability in oral administration. Casein hydrolysate (CL) has good interfacial diffusivity and emulsifying ability, and can interact with polysaccharides to form complexes combining the individual properties of both. Therefore, chitosan and casein hydrolysate are good candidates for developing nanoformulations for oral delivery. In this study, bioactive polysaccharides (OJPs), CS and CL, were combined to prepare CS/OJPs/CL co-assembled biodegradable nanoparticles. The interactions between polysaccharides (CS and OJPs) and peptide (CL) resulted in the formation of nanoparticles with an average particle size of 198 nm and high OJPs loading efficiency. The colloidal properties of the nanoparticles were pH-dependent, which were changed significantly in simulated digestive fluid at different pH values. OJPs released from the CS/OJPs/CL nanoparticles were greatly affected by pH and enzymatic degradation (trypsin and lysozyme). The nanoparticles were easily internalized by macrophages, thereby enhancing the OJPs’ inhibitory ability against Ni2+-induced cytotoxicity and LPS-induced nitric oxide production. This study demonstrates that prepared polysaccharide/protein co-assembled nanoparticles can be potential nanocarriers for the oral delivery of bioactive polysaccharides with anti-inflammatory functions.

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Design of polysaccharidic nano-in-micro soft agglomerates as primary oral drug delivery vehicle for colon-specific targeting

Cited by 19 publications

References 40 publications

A Multi-Component Nano-Co-Delivery System Utilizing Astragalus Polysaccharides as Carriers for Improving Biopharmaceutical Properties of Astragalus Flavonoids

A Multi-Component Nano-Co-Delivery System Utilizing Astragalus Polysaccharides as Carriers for Improving Biopharmaceutical Properties of Astragalus Flavonoids

Research Advances of Lipid Nanoparticles in the Treatment of Colorectal Cancer

Biodegradable Nanoparticles Prepared from Chitosan and Casein for Delivery of Bioactive Polysaccharides

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