Abstract-Post-installed anchorage is a widely used connection technology where the structural steel is connected with the concrete element by adhesive anchor especially in the field of strengthening and retrofitting engineering. ABAQUS software has been employed in this paper to analyze the seismic behavior of steel-to-concrete connections with consideration of different spacing and edge distance of anchor. The results show that there is strength reduction for steel-toconcrete connection under cyclic loading compared with static loading capacity. In parameter analysis of spacing, anchors with spacing 12d behave good performance in capacity and seismic energy dissipation. As for the study of edge distance, compared with static results the ultimate capacity of anchor in small edge distance has significant reduction because of incomplete concrete cone, connection with edge distance 10d under cyclic loading presents similar anchorage behavior with strength in static test. And the minimum value 8d of edge distance is proposed for practical design.Index Terms-Adhesive anchor, steel-to-concrete connection, seismic behavior, spacing, edge distance.