Design of silica carrier for controlled release of molsidomine: Effect of preparation methods of silica matrixes and their composites with molsidomine on the drug release kinetics in vitro

Parfenyuk, Elena V.; Dolinina, Ekaterina S.

doi:10.1016/j.ejpb.2014.09.007

Cited by 13 publications

(5 citation statements)

References 51 publications

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“…The release exponent n is in the range of 0.13-0.29 (<0.43), suggesting the diffusion-controlled release is by Fickian diffusion mechanism instead of corrosion. These results are in a good agreement with the previous reports of Hahn et al [37] and Parfenyuk et al [38] . Evidently, two factors including salt cation and pH should be considered as the release forces.…”

Section: Resultssupporting

confidence: 94%

Influence of Ionic Strength on the pH-sensitive in vitro Ibuprofen Release from Dextran-poly(acrylic acid) Copolymer

Zheng¹,

Sun²,

Jin³

et al. 2018

pharmaceutical-sciences

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Zhang, et al.: Influence of Ionic Strength on Ibuprofen ReleaseThe effects of cations and pH on the in vitro ibuprofen release from dextran-poly(acrylic acid) copolymer were investigated at varying pH and Na + or Ca 2+ concentrations. These results revealed that ibuprofen release was strongly depended on the acidic and basic environments, in which, the cumulative amount released in 24 h reached up to 87 % at pH 2.0 but only 32 % at pH 7.4, respectively, demonstrating a good pH-dependency. However, cations in release solution exerted a remarkable influence on ibuprofen release, especially in the acidic media. Meanwhile, ibuprofen release rate decreased with increasing strength of Na + , Ca 2+ and NaCl concentration. The zeta potential profiles and particle distributions at different ionic strengths indicated that cations strongly influence ibuprofen release performance, through surface charge, hydrogen-bonding, and electrostatic interactions in and between the polymer and ibuprofen. These results suggested that Na + and Ca 2+ strength exerted a profound influence on the pH-sensitive in vitro ibuprofen release from the dextranpoly(acrylic acid) copolymer.

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Section: Resultssupporting

confidence: 94%

Influence of Ionic Strength on the pH-sensitive in vitro Ibuprofen Release from Dextran-poly(acrylic acid) Copolymer

Zheng¹,

Sun²,

Jin³

et al. 2018

pharmaceutical-sciences

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“…Modern medicine focuses on local therapy [82] and it is believed that employing silica composites in local drug distribution has some benefits including: (1) the capacity to integrate significant quantities of broadly scattered or dissolved drugs at low temperatures during solidification procedures, (2) the assurance of efficient stabilization of the drug load towards deterioration due to moderately well host-guest interactions, (3) the regulated kinetics of drug release by adjusting the porous silica structure characteristics. Medicinal drugs such as molsidomine [83], bisphosphonate [84], itraconazole [85], ibuprofen, doxorubicin (DOX) [86], and vancomycin [87] have also been integrated into silica compounds, providing many potentials for both regulated deliveries of medicines and effective local therapy [88].…”

Section: Silica Composite Drug Carriersmentioning

confidence: 99%

Sol-gel: Uncomplicated, routine and affordable synthesis procedure for utilization of composites in drug delivery: Review

Azadani

Sabbagh²,

Salehi

et al. 2021

jcc

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“…The traditional routes to PSP are alkoxysilanes (Parfenyuk and Dolinina, 2014;Mohseni, 2015;Parfenyuk and Dolinina, 2017;Kierys, 2020). However, the toxicity of alkoxysilanes is well documented (Nakashima, 1998), and besides, their high cost (Essien, 2012) renders them unattractive for large-scale synthesis of PSP.…”

Section: Introductionmentioning

confidence: 99%

Modified Drug Release from SiO2/Polyhydroxybutyrate Composite Prepared Using Bamboo Leaf-Derived Silica

Essien¹

2022

Fabad Journal of Pharmaceutical Sciences

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The ability of a controlled or modified drug delivery system to supply the drug in a sustained way and assure on-demand bioavailability makes it preferable to traditional drug administration. Due to the reliance on alkoxysilane silica precursors, the preparation of silica/ polymer composite delivery material is costly. As a result, this study looked into using the bamboo leaf as a silica starting material. To evaluate in vitro degradability and modified-release in phosphatebuffered saline (PBS) solution, the ash from the bamboo leaf was mixed with polyhydroxy butyrate (PHB) solution to make a (SiO 2 / PHB) composite, which was then loaded with the medication, tetracycline hydrochloride (TCH). The shape, phase composition, and chemical bond characteristics of the materials were evaluated using scanning electron microscopy (SEM), X-ray diffractometry (XRD), and Fourier transform infrared spectroscopy. An ultraviolet (UV) spectrophotometer was used to determine the TCH release profile. The SiO 2 /PHB composite was found to have a successful drug loading ability. In addition to regulated degradability in PBS, the composite exhibited a steady and sustained TCH release, with the degradation solution pH remaining below safe limits. As a result, the formulation of SiO 2 /PHB for continuous TCH delivery from bamboo leaf-derived silica suggests a significant potential economic benefit for a safe, regulated drug delivery method.

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Design of silica carrier for controlled release of molsidomine: Effect of preparation methods of silica matrixes and their composites with molsidomine on the drug release kinetics in vitro

Cited by 13 publications

References 51 publications

Influence of Ionic Strength on the pH-sensitive in vitro Ibuprofen Release from Dextran-poly(acrylic acid) Copolymer

Influence of Ionic Strength on the pH-sensitive in vitro Ibuprofen Release from Dextran-poly(acrylic acid) Copolymer

Sol-gel: Uncomplicated, routine and affordable synthesis procedure for utilization of composites in drug delivery: Review

Modified Drug Release from SiO2/Polyhydroxybutyrate Composite Prepared Using Bamboo Leaf-Derived Silica

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