Abstract. We present a novel, fully-discriminative method for curvilinear structure segmentation that simultaneously learns a classifier and the features it relies on. Our approach requires almost no parameter tuning and, in the case of 2D images, removes the requirement for handdesigned features, thus freeing the practitioner from the time-consuming tasks of parameter and feature selection. Our approach relies on the Gradient Boosting framework to learn discriminative convolutional filters in closed form at each stage, and can operate on raw image pixels as well as additional data sources, such as the output of other methods like the Optimally Oriented Flux. We will show that it outperforms state-of-theart curvilinear segmentation methods on both 2D images and 3D image stacks.