Design of systems based on 4-armed star-shaped polyacids for indomethacin delivery

Abstract

The pentaerythritol based star-shaped polyacids as micellar nanocarriers with adjustable characteristics for drug delivery have been investigated.

How does the type of counterion influence the polymerization rate and thermal properties of tailored choline‐based linear‐ and star‐shaped poly(ionic liquid)s PILs?

“…As illustrated, there is only one endothermic event, related to the glass transition, independently on the molecular weight and the morphology of the polymer for all examined macromolecules. Note that a similar scenario was observed also in case of the other star‐shaped polymers, that is, copolymers containing methyl (meth)acrylate and (meth)acrylic acid . Values of the glass transition temperature, T g , determined from DSC measurements are presented as a function of M n in Figure (b).…”

Temperature and pH-Dependent Response of Poly(Acrylic Acid) and Poly(Acrylic Acid-co-Methyl Acrylate) in Highly Concentrated Potassium Chloride Aqueous Solutions

“…Poly(acrylic acid) (PAA) 7100 g/mol and poly(acrylic acid-co-methyl acrylate) (P(AA-co-MA)) g/mol was kindly provided by Dr. Shin-ichi Yusa. Pentaerythritol tetrakis(2-bromoisobutyrate) (PTLBr) was obtained according to a previously reported procedure [6]. Samples of commercially available PAA were obtained in the form of a 25% w/w aqueous solution (Sigma Aldrich, analytical grade).…”

“…Different system properties may serve as stimuli, such as temperature, pH, redox systems, light, ionic strength, or host-guest interactions. Therefore, stimuli-responsive polymers have been used as drug release agents, flocculants or flotation agents, switchable surfaces, or in chromatography, gene therapy, tissue engineering, biosensors, bioimaging, and optical switching [6][7][8][9][10][11][12][13][14][15][16][17][18]. Only a few publications have been dedicated to polymers with an upper critical solution temperature (UCST), in which the phase transition occurs between 273 and 373 K. In contrast, many studies have been performed on their counterparts with a lower critical 2 of 12 solution temperature (LCST), especially in the temperatures close to 309 K since they are meant as drug delivery systems in human body.…”

Retinol derivative as bioinitiator in the synthesis of hydroxyl-functionalized polymethacrylates for micellar delivery systems

“…In some cases of loaded systems (I, III, IV) the measurements showed a few generation of particles with different sizes in the sample, what may indicate the presence of unimers, as well as formation of micelles, aggregates, and even superaggregates (Figure 7). Generally the polymeric micelles are widely studied as the drug delivery systems, mostly for anti-cancer and anti-inflammatory therapy [34][35][36][37][38][39][40][41]. Satisfactory results have encouraged us to investigate the polymeric micelles also for encapsulation of cosmetic substances that improve the skin functions and appearance.…”