Design of Targeted Nanostructured Coordination Polymers (NCPs) for Cancer Therapy

Novio, Fernando

doi:10.3390/molecules25153449

Cited by 17 publications

(13 citation statements)

References 99 publications

(123 reference statements)

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“…The reason for the possibility of such phenomenon is the immaturity of the membrane of the endothelial cells and the anomalous basement membrane of capillaries in the tumor tissue, as well as the overproduction of proinflammatory mediators of the vessels that contribute to increased vascular permeability. These problems are widely discussed in today’s numerous reviews [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. In the tumor tissue, intercellular gap can be in the range 20–2000 nm [ 16 ], while in the vasculature in health tissue it is not higher than 5 nm.…”

Section: Introductionmentioning

confidence: 99%

Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier

et al. 2021

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The prospective strategy for treatment of cancer is based on the application of nano-sized macromolecular carriers, which are able penetrate inside and can be accumulated within tumor tissue. In this work graft copolymers of cellulose and poly(methacrylic acid) has been prepared and tested as a nanocontainers for the delivery of drug to tumor. For this purpose, two derivatives of porphyrazine suitable for photodynamic cancer therapy were loaded into prepared polymer brush. Fluorescence imaging was applied for monitoring of accumulation of porphyrazine in the CT26 murine colon carcinoma. The selective accumulation of cellulose brush loaded with porphyrazine in tumor was demonstrated by fluorescence intensity contrast between the tumor area and normal tissues. The tumor growth rate after photodynamic therapy were assessed and inhibition of its growth was revealed.

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Section: Introductionmentioning

confidence: 99%

Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier

et al. 2021

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“…The internalization of nanocomposites into targeted cells is of paramount importance for nanoparticulate drug delivery systems [ 53 ]. A common strategy for enhancing the internalization of NPs in cancer cells is to decorate the surface of NPS with targeted ligands [ 54 ]. The FOLR has been reported to be overexpressed in various cancer cells, including OS cells [ 39 , 40 ].…”

Section: Resultsmentioning

confidence: 99%

Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy

Yang

Liang

et al. 2021

J Nanobiotechnol

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Background Despite advances of surgery and neoadjuvant chemotherapy during the past few decades, the therapeutic efficacy of current therapeutic protocol for osteosarcoma (OS) is still seriously compromised by multi-drug resistance and severe side effects. Amplification of intracellular oxidative stress is considered as an effective strategy to induce cancer cell death. The purpose of this study was to develop a novel strategy that can amplify the intracellular oxidative stress for synergistic cascade cancer therapy. Methods and results A novel nanocomposite, composed of folic acid (FA) modified mesoporous silica–coated gold nanostar (GNS@MSNs-FA) and traditional Chinese medicine lycorine (Ly), was rationally designed and developed. Under near-infrared (NIR) irradiation, the obtained GNS@MSNs-FA/Ly could promote a high level of ROS production via inducing mitochondrial dysfunction and potent endoplasmic reticulum (ER) stress. Moreover, glutathione (GSH) depletion during ER stress could reduce ROS scavenging and further enable efficient amplification of intracellular oxidative stress. Both in vitro and in vivo studies demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation exhibited excellent antitumor efficacy without noticeable toxicity in MNNG/HOS tumor-bearing mice. Conclusion All these results demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation could dramatically amplify the intra-tumoral oxidative stress, exhibiting excellent antitumor ability without obvious systemic toxicity. Taken together, this promising strategy provides a new avenue for the effective cancer synergetic therapy and future clinical translation.

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“…The internalization of nanocomposites into targeted cells is of paramount importance for nanoparticulate drug delivery systems [52]. Decorating a targeting ligand on the surface of the nanoparticles is a common strategy to improve cancer cell internalization of nanoparticles [53]. The FOLR has been reported to be overexpressed in various cancer cells, including OS cells [37,38].…”

Section: Cellular Uptakementioning

confidence: 99%

Amplification of Oxidative Stress With Lycorine and Gold-Based Nanocomposites for Synergistic Cascade Cancer Therapy

Yang

Liang

et al. 2021

Preprint

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BackgroundDespite advances of surgery and neoadjuvant chemotherapy during the past few decades, the therapeutic efficacy of current therapeutic protocol for osteosarcoma (OS) is still seriously compromised by multi-drug resistance and severe side effects. Amplification of intracellular oxidative stress is considered as an effective strategy to induce cancer cell death. The purpose of this study was to develop a novel strategy that can amplify the intracellular oxidative stress for synergistic cascade cancer therapy.Methods and resultsA novel nanocomposite, composed of folic acid (FA) modified mesoporous silica–coated gold nanostars (GNS@MSNs-FA) and traditional Chinese medicine Lycorine (Ly), was rationally designed and developed. Under near-infrared (NIR) irradiation, the obtained GNS@MSNs-FA/Ly could promote a high level of ROS production via inducing mitochondrial dysfunction and potent endoplasmic reticulum (ER) stress. Moreover, glutathione (GSH) depletion during ER stress could reduce ROS scavenging and further enable efficient amplification of intracellular oxidative stress. Both in vitro and in vivo studies demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation exhibited excellent antitumor efficacy without noticeable toxicity in MNNG/HOS tumor-bearing mice.ConclusionAll these results demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation dramatically was able to amplify the intra-tumoral oxidative stress, exhibiting excellent antitumor ability without no obvious systemic toxicity. Taken together, this promising strategy provides a new avenue for the effective cancer synergetic therapy and future clinical translation.

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Design of Targeted Nanostructured Coordination Polymers (NCPs) for Cancer Therapy

Cited by 17 publications

References 99 publications

Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier

Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier

Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy

Amplification of Oxidative Stress With Lycorine and Gold-Based Nanocomposites for Synergistic Cascade Cancer Therapy

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