Design of the circulation improving resuscitation care (CIRC) trial: A new state of the art design for out-of-hospital cardiac arrest research

Lerner, E. Brooke; Persse, David; Souders, Chris M.; Sterz, Fritz; Malzer, Reinhard; Lozano, Michael; Westfall, Mark; Brouwer, Marc A.; Grunsven, P.M. van; Whitehead, Anne; Olsen, Jan-Aage; Herken, Ulrich

doi:10.1016/j.resuscitation.2010.09.095

Cited by 10 publications

(13 citation statements)

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“…[16] The duration of CPR is a good predictor of outcome as demonstrated by us and numerous others. [17][18][19] In our study, CPR duration of 30 minutes was taken as a cut off and it was found that out of 59% patients with OHCA, who received CPR for a duration of less than or equal to 30 minutes, ROSC was achieved in 32.5% of them whereas not a single patient could be revived in the remaining 32.5% of patients, who received CPR for a duration of more than 30 minutes. This shows that the CPR duration of more than 30 minutes in OHCA patients is associated with very poor outcome.…”

Section: Discussionmentioning

confidence: 85%

Out of hospital cardiac arrest resuscitation outcome in North India — CARO study

Krishna¹,

Showkat²,

Taktani³

et al. 2017

World Journal of Emergency Medicine

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BACKGROUND:To evaluate the outcome of cardiopulmonary resuscitation (CPR) in out-ofhospital cardiac arrests (OHCA) in India and factors infl uencing the outcome. METHODS:The outcome and related factors like demographics, aspects of the OHCA event, return of spontaneous circulation (ROSC) and survival to discharge, among the 80 adult patients presenting to emergency department experiencing OHCA considered for resuscitation between January 2014 to April 2015, were analyzed, according to the guidelines of the Utstein consensus conference. RESULTS:The survival rate to hospital admission was 32.5%, the survival rate to hospital discharge was 8.8% and with good cerebral performance category (CPC1) neurological status was 3.8%. Majority of OHCA was seen in elderly individuals between 51 to 60 years, predominately in males. Majority of OHCA were witnessed arrests (56.5%) with 1.3% bystander CPR rate, 92.5% arrests occurred at home, 96% presented with initial non-shockable rhythm and 92.5% with presumed cardiac etiology but survival was better in those who experienced OHCA at public place, in witnessed arrests, in patients who had shockable presenting rhythm and in those where CPR duration was ≤20 minutes. CONCLUSION:Witnessed arrests, early initiation of CPR by bystanders, CPR duration ≤20 minutes, initial presenting shockable rhythm, OHCA with non-cardiac etiology are associated with a good outcome. To improve the outcome of CPR and the low survival rates after an OHCA event in India, focused strategies should be designed to set up an emergency medical system (EMS), to boost the rates of bystander CPR and education of the lay public in basic CPR.

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Section: Discussionmentioning

confidence: 85%

Out of hospital cardiac arrest resuscitation outcome in North India — CARO study

Krishna¹,

Showkat²,

Taktani³

et al. 2017

World Journal of Emergency Medicine

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“…Sites transitioned from one phase to another based on pre‐specified protocol criteria. This design was chosen to reduce a possible Hawthorne effect and other biases . For analysis of the main trial, the Group Sequential Double Triangular Test was used.…”

Section: Methodsmentioning

confidence: 99%

Chest compression duration influences outcome between integrated load‐distributing band and manual CPR during cardiac arrest

Olsen

Lerner

Persse

et al. 2015

Acta Anaesthesiol Scand

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“…Once again, these observation studies are prone to bias, a fact underlined by a reanalysis of a Nor wegian prospective study [21]. We await publication of the results of studies on two mechanical CPR devices: the loaddistrib uting band [22] and the LUCAS [23,24]. I anticipate that results from all of these trials will be available to inform the dis cussion leading into the 2015 internation al consensus on CPR science conference.…”

Section: The International Liaison Committee On Resuscitation (Ilcor)mentioning

confidence: 99%

The International Liaison Committee on Resuscitation (ILCOR) process for developing guidelines

Nolan

2013

Notfall Rettungsmed

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Design of the circulation improving resuscitation care (CIRC) trial: A new state of the art design for out-of-hospital cardiac arrest research

Cited by 10 publications

References 0 publications

Out of hospital cardiac arrest resuscitation outcome in North India — CARO study

Out of hospital cardiac arrest resuscitation outcome in North India — CARO study

Chest compression duration influences outcome between integrated load‐distributing band and manual CPR during cardiac arrest

The International Liaison Committee on Resuscitation (ILCOR) process for developing guidelines

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