Design of the micropump and mass-transfer compartment of a microfluidic system for regular nonenzymatic glucose measurement

Najmi, Armita; Saidi, Mohammad R.; Hannani, Siamak Kazemzadeh

doi:10.1016/j.btre.2022.e00723

Cited by 7 publications

(10 citation statements)

References 42 publications

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“…Overall, studies show that MNs are mainly used in microfluidic applications for biomarker detection [ 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ], cargo delivery [ 69 , 70 , 71 , 72 , 73 ], and cell microinjection [ 74 , 75 ]. Table 1 shows the types of MNs, materials, applications and hydrodynamic forces used in microfluidic devices.…”

Section: Resultsmentioning

confidence: 99%

“…In some revised works, planar micropumps were used because of their advantage in being simple to integrate and having the ability to change the flow operation (extraction/injection) by just flipping the valve direction. For LoC devices with in-plane MNs, this approach is further explored [ 60 , 70 ], although leaks between the inlet and outlet can occur.…”

Section: Resultsmentioning

confidence: 99%

“…As a possible solution, Najmi et al, 2022, developed and simulated a nonenzymatic glucose detection device by integrating a microfluidic system and a semi-permeable membrane located at the MN base to separate the dialysis fluid from the waste fluid. In this case, an amperometric sensor was used [ 60 ]. However, some leakage was observed from outlet-to-inlet ( Figure 4 B).…”

Section: Resultsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications

et al. 2023

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Microneedles (MNs) have been widely used in biomedical applications for drug delivery and biomarker detection purposes. Furthermore, MNs can also be used as a stand-alone tool to be combined with microfluidic devices. For that purpose, lab- or organ-on-a-chip are being developed. This systematic review aims to summarize the most recent progress in these emerging systems, to identify their advantages and limitations, and discuss promising potential applications of MNs in microfluidics. Therefore, three databases were used to search papers of interest, and their selection was made following the guidelines for systematic reviews proposed by PRISMA. In the selected studies, the MNs type, fabrication strategy, materials, and function/application were evaluated. The literature reviewed showed that although the use of MNs for lab-on-a-chip has been more explored than for organ-on-a-chip, some recent studies have explored this applicability with great potential for the monitoring of organ models. Overall, it is shown that the presence of MNs in advanced microfluidic devices can simplify drug delivery and microinjection, as well as fluid extraction for biomarker detection by using integrated biosensors, which is a promising tool to precisely monitor, in real-time, different kinds of biomarkers in lab- and organ-on-a-chip platforms.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications

et al. 2023

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“…Hence, the low extraction rate (from 10 µL/min to a few hundred microliters) is painless [69] and suitable for transdermal application [70,71]. 1 µL/min flow rate is appropriate flow rate for maximizing recovery factor (RF) and obtaining high accuracy measurement in detection biosensor [72]. The recovery factor (RF), which is the ratio of the glucose concentration in the extracted ISF to the fresh ISF in the skin, can be calculated using Equation (1).…”

Section: Proposed Concept Designmentioning

confidence: 99%

Finger-Actuated Micropump of Constant Flow Rate without Backflow

et al. 2023

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This paper presents a finger-actuated micropump with a consistent flow rate and no backflow. The fluid dynamics in interstitial fluid (ISF) extraction microfluidics are studied through analytical, simulation, and experimental methods. Head losses, pressure drop, diodocity, hydrogel swelling, criteria for hydrogel absorption, and consistency flow rate are examined in order to access microfluidic performance. In terms of consistency, the experimental result revealed that after 20 s of duty cycles with full deformation on the flexible diaphragm, the output pressure became uniform and the flow rate remained at nearly constant levels of 2.2 μL/min. The flow rate discrepancy between the experimental and predicted flow rates is around 22%. In terms of diodicity, when the serpentine microchannel and hydrogel-assisted reservoir are added to the microfluidic system integration, the diodicity increases by 2% (Di = 1.48) and 34% (Di = 1.96), respectively, compared to when the Tesla integration (Di = 1.45) is used alone. A visual and experimentally weighted analysis finds no signs of backflow. These significant flow characteristics demonstrate their potential usage in many low-cost and portable microfluidic applications.

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Exploring the potential of microfluidics for next-generation drug delivery systems

et al. 2023

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Design of the micropump and mass-transfer compartment of a microfluidic system for regular nonenzymatic glucose measurement

Cited by 7 publications

References 42 publications

Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications

Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications

Finger-Actuated Micropump of Constant Flow Rate without Backflow

Exploring the potential of microfluidics for next-generation drug delivery systems

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