Design of the Saitama Cardiometabolic Disease and Organ Impairment Study (SCDOIS): A Multidisciplinary Observational Epidemiological Study

Muneyuki, Toshitaka; Suwa, Kaname; Oshida, Haruki; Takaoka, Tomoya; Kutsuma, Ayano; Yoshida, Tsukasa; Saito, Masafumi; Hori, Yumiko; Kannno, Yoshihiko; Kanda, Eiichiro; Kakei, Masafumi; Momomura, Shin‐ichi; Nakajima, Kei

doi:10.4236/ojemd.2013.32022

Cited by 15 publications

(24 citation statements)

References 96 publications

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“…This preliminary cross-sectional study was part of an observational study that was performed to examine the relationships between lifestyle-related diseases and cardiometabolic risk factors (Muneyuki et al 2013). The current study involved 2 institutions in Kanagawa and Saitama, Japan: Kanagawa University of Human Services and the Saitama Health Promotion Corporation, a public interest corporation.…”

Section: Methodsmentioning

confidence: 99%

“…BMI was calculated as body weight (kg) divided by height squared (m 2 ). Subjects were divided into six BMI categories (≤18.9, 19.0–20.9, 21.0–22.9, 23.0–24.9, 25.0–26.9, and ≥ 27.0 kg/m 2 ), as previously reported (Muneyuki et al 2013).…”

Section: Methodsmentioning

confidence: 99%

“…Significant differences in parameteres between BMI categories were evaluated using analysis of variance (ANOVA). Differences between subjects with a provisional reference BMI of 21.0–22.9 kg/m 2 (Muneyuki et al 2013, WHO Expert Consultation. 2004) and other BMI groups, and differences between the five age groups were evaluated using the post-hoc Bonferroni test and the Mann–Whitney test.…”

Section: Methodsmentioning

confidence: 99%

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Elevated serum aspartate aminotransferase levels concomitant with normal alanine aminotransferase levels in older low body weight people: Preliminary findings from a community-based epidemiological study

Shibata

Nakajima

2019

Preprint

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BackgroundSerum enzyme levels, including hepatic transaminase, are unknown in older people with low body weight (LBW), who can easily experience sarcopenia. Therefore, we addressed preliminarily this issue in a cross-sectional study of an apparently healthy population. MethodsWe investigated the relationship of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and total bilirubin levels with body mass index (BMI) and age in 79,623 subjects aged 20-80 years who underwent an annual checkup. ResultsSerum levels of AST, ALP, and LDH levels were significantly higher in older (≥50 years) non-obese subjects compared with younger (< 50 years) corresponding subjects. Serum AST levels were significantly higher in older LBW subjects (BMI ≤ 18.9 kg/m 2 ) than in those with a reference BMI of 20.9-22.9 kg/m 2 . Serum AST levels showed a J-shaped curve against BMI, whereas ALT and GGT levels showed a linear relationship, regardless of age. ConclusionElevated serum AST levels concomitant with normal ALT levels, which might reflect systemic damage of skeletal muscle, may be prevalent in older LBW people. Further studies need to determine whether such a condition is equivalent to the etiology of sarcopenia. Elevated serum aspartate aminotransferase levels concomitant with normal alanine1 aminotransferase levels in older low body weight people: Preliminary findings from a 2 community-based epidemiological study 3 4 Abstract 1Background. Serum enzyme levels, including hepatic transaminase, are unknown in older 2 people with low body weight (LBW), who can easily experience sarcopenia. Therefore, we 3 addressed preliminarily this issue in a cross-sectional study of an apparently healthy 4 population.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Elevated serum aspartate aminotransferase levels concomitant with normal alanine aminotransferase levels in older low body weight people: Preliminary findings from a community-based epidemiological study

Shibata

Nakajima

2019

Preprint

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“…The design of this study is described in more detail elsewhere [17]. This retrospective study consists of data recorded during annual medical checkups of asymptomatic individuals living or working in Saitama Prefecture, a suburb of Tokyo, Japan.…”

Section: Methodsmentioning

confidence: 99%

Subclinical Hearing Loss, Longer Sleep Duration, and Cardiometabolic Risk Factors in Japanese General Population

Nakajima

Kanda²,

Hosobuchi

et al. 2014

International Journal of Otolaryngology

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Hearing loss leads to impaired social functioning and quality of life. Hearing loss is also associated with sleeping disorders and cardiometabolic risk factors. Here, we determined whether subclinical hearing loss is associated with sleep duration and cardiometabolic risk factors in a cross-sectional and longitudinal study of healthy Japanese general population. 48,091 men and women aged 20–79 years who underwent medical checkups were included in a cross-sectional study, and 6,674 were included in an 8-year longitudinal study. The prevalence of audiometrically determined hearing loss (>25 dB) at 4000 and 1000 Hz increased significantly with increasing sleep duration in any age strata. Logistic regression analysis showed that compared with reference sleep duration (6 h) longer sleep duration (≥8 h) was significantly associated with hearing loss, even after adjusting for potential confounding factors. Simultaneously, hearing loss was significantly associated with male sex, diabetes, and no habitual exercise. In the longitudinal study, the risk of longer sleep duration (≥8 h) after 8 years was significantly greater in subjects with hearing loss at 4000 Hz at baseline. In conclusion, current results suggest a potential association of subclinical hearing loss with longer sleep duration and cardiometabolic risk factors in a Japanese general population.

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“…clinical significance (1,7,8). However, several studies have suggested that TrP is highly likely to progress to microalbuminuria (3,7,9).…”

mentioning

confidence: 99%

Asymptomatic trace and overt proteinuria in high- and lowbody weight individuals: A preliminary report of communitybased epidemiological study

Nakajima¹,

Kanda²,

Muneyuki³

et al. 2017

J Nephropathol

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Implication for health policy/practice/research/medical education:The prevalence of trace proteinuria assessed by dipstick urinalysis demonstrated J-shaped relationship against body mass index similarly to overt proteinuria. However, the degree and pattern of associations of trace proteinuria with body mass index may differ from those of overt proteinuria. Please cite this paper as: Nakajima K, Kanda E, Muneyuki T, Suwa K. Asymptomatic trace and overt proteinuria in high-and low-body weight individuals: A preliminary report of community-based epidemiological study. J Nephropathol. 2018;7(2):51-56.Background: Overt proteinuria (OP), an established risk factor for kidney and cardiovascular disease, is much prevalent in high and low body weight individuals. Objectives: However, it is equivocal whether trace proteinuria (TrP) is also associated with high and low body weight. Therefore, we address this issue in a large epidemiological study. Patients and Methods: Regarding this association, we examined TrP defined as ± by dipstick urinalysis, in comparison with OP (≥+1) using the data of 70 886 apparently healthy Japanese men and women who underwent a checkup in 2008, aged 20-85 years old. Results: The prevalence of TrP, which was slightly but significantly higher (4.1%) on average compared with OP (3.1%), showed a J-shaped relationship against body mass index (BMI). Logistic regression analysis showed that compared to BMI of 21.0-22.9 kg/m 2 , other BMI categories except BMI of 19.0-20.9 kg/m 2 were significantly associated with TrP, which were not altered after adjustment for relevant confounding factors including age, sex, and pharmacotherapies for hypertension and diabetes. Unlike TrP, OP was not significantly associated with BMI of 23.0-24.9 kg/m 2 , a high-normal body weight, although similar trends were observed in the overall relationship between BMI categories and OP. Conclusions: Current study suggests that TrP is also associated with high and low body weight, seemingly like OP. However, the degree and pattern of associations of TrP with BMI may differ from those of OP. Further study is required particularly in terms of fundamental clinical relevance of TrP.

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Design of the Saitama Cardiometabolic Disease and Organ Impairment Study (SCDOIS): A Multidisciplinary Observational Epidemiological Study

Cited by 15 publications

References 96 publications

Elevated serum aspartate aminotransferase levels concomitant with normal alanine aminotransferase levels in older low body weight people: Preliminary findings from a community-based epidemiological study

Elevated serum aspartate aminotransferase levels concomitant with normal alanine aminotransferase levels in older low body weight people: Preliminary findings from a community-based epidemiological study

Subclinical Hearing Loss, Longer Sleep Duration, and Cardiometabolic Risk Factors in Japanese General Population

Asymptomatic trace and overt proteinuria in high- and lowbody weight individuals: A preliminary report of communitybased epidemiological study

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