Design of thermosensitive polymer‐coated magnetic mesoporous silica nanocomposites with a core‐shell‐shell structure as a magnetic/temperature dual‐responsive drug delivery vehicle

Abstract

A stimuli-responsive nanocomposite with a core-shell-shell structure consisting of iron oxide (Fe 3 O 4 ) nanoparticles as core, mesoporous silica as middle shell, and poly(Nisopropyl acrylamide-co-acrylic acid) (P[NIPAAm-co-AAc]) as an exterior shell with thermo-responsivity properties was synthesized to be used as a magnetic/temperature responsive drug delivery system. The structure, morphology, and size of P(NIPAAm-co-AAc)-coated mesoporous silica embedded magnetite nanoparticles (P(NIPAAm-co-AAc) @mSiO 2 @Fe 3 O 4 ) were characterized by XRD, FTIR, and TEM analyses. Also, the heating ability of mesoporous silica-coated Fe 3 O 4 nanoparticles, and P(NIPAAm-co-AAc) @mSiO 2 @Fe 3 O 4 nanocomposites was investigated under the exposure of an alternating magnetic field (AMF). The results indicated that the prepared nanocomposites could generate enough heat for hyperthermia applications. Moreover, the magnetic/temperatureresponsive drug release behavior of P(NIPAAm-co-AAc)@mSiO 2 @Fe 3 O 4 nanocomposites loaded with fluorouracil (5-FU) was studied under the exposure of the AMF (frequency = 120 kHz, and amplitude = 22 kA m À1 ), as well as two different temperatures (37 C and 45 C). The results showed that only 7.8% of the drug could be released after 20 h at 37 C (below the LCST of the copolymer). In contrast, by increasing the temperature of release medium up to 45 C (above the LCST of the copolymer), the amount of released drug was increased up to 47%. Moreover, by exposing the prepared nanocomposite to a safe AMF, a burst release of drug was observed, indicating the excellent responsivity of the carrier to an external magnetic field. These results proved that the obtained nanocomposite has a great performance to be used as a magnetic/temperature-sensitive drug carrier for advanced drug delivery applications.

pH‐sensitive folic acid/poly(vinyl pyrrolidone) functionalized MnFe2O4/single‐walled carbon nanotubes for release of a natural anticancer agent: Chlorogenic acid

“…PVP/MnFe 2 O 4 /SWCNT–FA had a maximum of M s near 7.6 emu/g, which was significantly lower than that of the corresponding pure bulk MnFe 2 O 4 value of 78.1 emu/g. The much weaker magnetic property of the PVP/MnFe 2 O 4 /SWCNT–FA can be ascribed to the presence of a large number of diamagnetic components, such as PVP, FA, and SWCNT in the prepared nanohybrid 34 …”

Recent Advances Ultra-Porous Drug Nano-Carriers: Synthesis and Targeting Approaches

“…Further, Asgari et al [159] created a mesoporous silica layer on iron oxide NPs. Radical polymerization was used to attach NIPAM copolymerized with acrylic acid to the surface of silica.…”

Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery

“…Several studies have combined metallic nanoparticles with polymers for this purpose. The use of a polymer helps with the compatibility of the particles, can incorporate an active target, and increase the circulation time [29,30,[98][99][100]. However, the magnetic properties of these systems is achieved by the metallic nanoparticles, such as iron as was used in the studies by Cao et al [29] and García-García et al [30] They both used polymers as a coating on the iron nanoparticles to achieve better biocompatibility and targeting.…”