Design, optimization and pharmacokinetics of novel prolonged gastroretentive drug delivery system of quetiapine fumarate

Mehta, Dharmik M.; Parejiya, Punit B.; Patel, Hetal; Trivedi, Palak; Suthar, Disha D.; Shelat, Pragna K.

doi:10.1007/s40005-016-0237-0

Cited by 8 publications

(2 citation statements)

References 12 publications

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“…Additionally, the presence of sodium bicarbonate can overcome tablet floatability issues in cases where high tablet compaction forces result in low tablet porosity values that are insufficient for floatation [17]. Additionally, in other cases, one layer consists of the drug, release retardant(s) and other excipients, while the other layer is the gastroretentive layer containing the gas-generating agent(s) and hydrophilic polymer(s) [86]. Cifran ® OD is a ciprofloxacin commercial product that constitutes effervescent single-layer gastroretentive tablets coated with a polymer film that is responsible for tablet buoyancy.…”

Section: Effervescent Floating Systemsmentioning

confidence: 99%

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Gastroretentive Technologies in Tandem with Controlled-Release Strategies: A Potent Answer to Oral Drug Bioavailability and Patient Compliance Implications

2021

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There have been many efforts to improve oral drug bioavailability and therapeutic efficacy and patient compliance. A variety of controlled-release oral delivery systems have been developed to meet these needs. Gastroretentive drug delivery technologies have the potential to achieve retention of the dosage form in the upper gastrointestinal tract (GIT) that can be sufficient to ensure complete solubilisation of the drugs in the stomach fluids, followed by subsequent absorption in the stomach or proximal small intestine. This can be beneficial for drugs that have an “absorption window” or are absorbed to a different extent in various segments of the GIT. Therefore, gastroretentive technologies in tandem with controlled-release strategies could enhance both the therapeutic efficacy of many drugs and improve patient compliance through a reduction in dosing frequency. The paper reviews different gastroretentive drug delivery technologies and controlled-release strategies that can be combined and summarises examples of formulations currently in clinical development and commercially available gastroretentive controlled-release products. The different parameters that need to be considered and monitored during formulation development for these pharmaceutical applications are highlighted.

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Section: Effervescent Floating Systemsmentioning

confidence: 99%

“…Non-Effervescent Tablets Single-layer and bilayer floating tablets are another category of non-effervescent floating systems. For gastric retention, usually hydrophilic polymers such as HPMC, HPC, sodium alginate, PEO are used [13,17,[85][86][87].…”

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confidence: 99%