Design, optimization and scale-up of a new micromixer design based on plate column for organic synthesis

Santana, Harrson Silva; Haddad, Victória Anselmo; Calvo, P.; Palma, Mauri Sérgio Alves; Silva, Adriano G. P. da; Noriler, Dirceu; Taranto, Osvaldir Pereira; Silva, João L.

doi:10.1016/j.cej.2022.137159

Cited by 21 publications

(3 citation statements)

References 56 publications

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“…At present, researchers have proposed many mixers based on different mixing principles to improve mass and heat transfer in continuous flow chemical processes. Santana et al [ 10 ] introduced plate column tray obstacles in the Y‐type mixer, increasing the mixing efficiency to 97%. Le The et al [ 11 ] designed and fabricated a shifted trapezoidal blades (STB) micromixer by the combination of several mixing principles, including vortices, transversal flows, and chaotic advection, providing high mixing efficiency even at a low Reynolds number.…”

Section: Introductionmentioning

confidence: 99%

Improvement of mass and heat transfer efficiency in a scale‐up microfluidic mixer designed by CFD simulation

Nie

Zhao

et al. 2023

Can J Chem Eng

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Due to scale effects, directly enlarging the size of the micromixer is an easy way to reduce the efficiency of mass and heat transfer in the continuous flow chemical process. It is urgently needed to solve the problem of mass and heat transfer efficiency of the scale‐up mixer. A scale‐up microfluidic mixer with a porous structure was designed to improve the mass and heat transfer efficiency using computational fluid dynamics (CFD) simulations. The effects of rotation angle, porosity, and baffle spacing were studied to optimize the mixer structure. Compared with the 1 mm mixer without structure, the scale‐up mixer has a higher mixing efficiency and an 80% reduction in energy consumption at Re ≥ 700. A Nusselt number was used to evaluate the heat transfer efficiency of the mixer during fluid heating. The results show that the porous baffle promotes the generation of secondary flow and enhances the heat transfer effect, making its Nu increase by three times compared with the unstructured mixer. The scale‐up microfluidic mixer with a porous structure can effectively improve the mass and heat transfer performance. This study can provide a reference for the design or development of a novel scale‐up mixer.

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Section: Introductionmentioning

confidence: 99%

Improvement of mass and heat transfer efficiency in a scale‐up microfluidic mixer designed by CFD simulation

Nie

Zhao

et al. 2023

Can J Chem Eng

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“…Two scaling-up strategies, i.e., the numbering-up and the selective scaling-out, have been used to increase the processing capacity of passive micromixers. − The numbering-up strategy that has been most widely used is a parallelization method, in which multiple identical submicromixers are used to form a tree-like or ladder-like network of microchannels. However, the complex network significantly increases the manufacturing and operating costs.…”

Section: Introductionmentioning

confidence: 99%

Selective Scaling-out of a Serpentine Micromixer: Scaling Criteria

Wang,

Li,

2023

Ind. Eng. Chem. Res.

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A serpentine micromixer (SMM) is a high-efficiency chaotic micromixer due to the high mixing efficiency caused by the Dean flow. A novel scaling method, the selective scaling-out strategy, can be used to significantly increase fluxes, facilitating the application of SMMs in industrial production. However, no criteria for the selective scale-out of SMMs are available. In this article, a series of scaled-out SMMs were numerically studied at fluxes of up to 150 mL/min. The hydrodynamic properties of these SMMs were investigated using the residence time distribution (RTD), Euler number, shape factor, Peclet number, and mass-averaged energy dissipation rate. As a result, three scaling criteria were determined to characterize the pressure drop, RTD characteristics (variance and mean residence time), and degree of micromixing during the scale-out of SMMs. The three scaling criteria can help designers easily scale out an SMM and facilitate the application of SMMs in large-scale production.

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“…CFD simulation is an effective and practical tool for the prediction of fluid flow as well as heat and mass transfer in microreactors. CFD modeling and simulation are exceptional because they are able to study the process visually and quantitatively as well as the effect of changes in design and operating conditions on the system performance [14][15][16]. CFD was used to investigate the synthetic process for the ionic liquid 1-butyl-3-methylimidazolium chloride in a flow microreactor [14].…”

Section: Introductionmentioning

confidence: 99%

Modeling and Simulation of N‐(3‐Aminio‐4 methylphenyl)benzamide Synthesis in a Microreactor

Cao,

Ghadiri

2023

Chem Eng & Technol

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N‐(3‐Amino‐4‐methylphenyl)benzamide is an intermediate product for the production of several medicines. Microreactor technology is a new concept for the continuous synthesis of chemicals. The computational fluid dynamics method was used to simulate the flow synthesis of N‐(3‐amino‐4‐methylphenyl)benzamide. There was good agreement between experimental data and modeling outputs. The effect of operating parameters such as temperature and residence time on system performance was investigated. The results revealed that an increase in temperature from 30 to 70 °C led to the enhancement of N‐(3‐amino‐4‐methylphenyl)benzamide production from about 42 to 76 % at a residence time of 420 s. It was found that the residence time and temperature have the largest influence on N‐(3‐amino‐4‐methylphenyl)benzamide production. Byproduct production was also increased by increasing the temperature and residence time.

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Design, optimization and scale-up of a new micromixer design based on plate column for organic synthesis

Cited by 21 publications

References 56 publications

Improvement of mass and heat transfer efficiency in a scale‐up microfluidic mixer designed by CFD simulation

Improvement of mass and heat transfer efficiency in a scale‐up microfluidic mixer designed by CFD simulation

Selective Scaling-out of a Serpentine Micromixer: Scaling Criteria

Modeling and Simulation of N‐(3‐Aminio‐4 methylphenyl)benzamide Synthesis in a Microreactor

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