Design, Organization and Management of a Controlled Population Screening Study for Detection of Colorectal Neoplasia: Attendance Rates in the NORCCAP Study (Norwegian Colorectal Cancer Prevention)

Bretthauer, Michael; Gondal, Ghous; Larsen, Inger Kristin; Carlsen, Esben Andreas; Eide, T. J.; Grotmol, Tom; Skovlund, Eva; Tveit, Kjell Magne; Vatn, Morten H.; Hoff, Geir

doi:10.1080/00365520252903125

Cited by 87 publications

(72 citation statements)

References 16 publications

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“…Sigmoidoscopy was found to be acceptable, feasible, and safe in ongoing trials in the United Kingdom, Italy, Norway, and the United States (26)(27)(28)(29). Acceptability and feasibility may be lower for colonoscopy, partly due to limited resources in highly qualified personnel (30), but pertinent data are sparse.…”

Section: Discussionmentioning

confidence: 99%

“…Control for multiple potential confounders only had a minor effect on estimates of ORs, but one can never rule out residual confounding by imperfectly measured confounders or unmeasured confounders by an observational study like this one. The results of the randomized controlled trials, which are under way in Europe and the United States (26)(27)(28)(29), will have to be awaited to obtain more definitive answers on the risk reduction that may be achieved by endoscopic screening.…”

Section: Discussionmentioning

confidence: 99%

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Potential for Colorectal Cancer Prevention of Sigmoidoscopy Versus Colonoscopy: Population-Based Case Control Study

Brenner¹,

Chang‐Claude

Seiler

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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We aimed to estimate the proportions of colorectal cancer cases that might be prevented by sigmoidoscopy compared with colonoscopy among women and men. In a populationbased case control study conducted in Germany, 540 cases with a first diagnosis of primary colorectal cancer and 614 controls matched for age, sex, and county of residence were recruited. A detailed lifetime history of endoscopic examinations of the large bowel was obtained by standardized personal interviews, validated by medical records, and compared between cases and controls, paying particular attention to location of colorectal cancer and sex differences. Overall, 39%, 77%, and 64% of proximal, distal, and total colorectal cancer cases were estimated to be preventable by colonoscopy. The estimated proportion of total colorectal cancer cases preventable by sigmoidoscopy was 45% among both women and men, assuming that sigmoidoscopy reaches the junction of the descending and sigmoid colon only and findings of distal polyps are not followed by colonoscopy. Assuming that sigmoidoscopy reaches the splenic flexure and colonoscopy is done after detection of distal polyps, estimated proportions of total colorectal cancer preventable by sigmoidoscopy increase to 50% and 55% (73% and 91% of total colorectal cancer preventable by primary colonoscopy) among women and men, respectively. We conclude that colonoscopy provides strong protection against colorectal cancer among both women and men. The proportion of this protection achieved by sigmoidoscopy with follow-up colonoscopy in case of distal polyps may be larger than anticipated. Among men, this regimen may be almost as effective as colonoscopy, at least at previous performance levels of colonoscopy. (Cancer Epidemiol Biomarkers Prev 2007;16(3):494 -9)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Potential for Colorectal Cancer Prevention of Sigmoidoscopy Versus Colonoscopy: Population-Based Case Control Study

Brenner¹,

Chang‐Claude

Seiler

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Recruitment took place from 1999 to 2001 at 2 hospitals (screening centers), one in each catchment area. Several lifestyle variables were recorded, and blood samples were collected (13 ). The study was approved by the Regional Ethics Committee and the Data Inspectorate.…”

Section: Participantsmentioning

confidence: 99%

Coffee Consumption and Circulating B-Vitamins in Healthy Middle-Aged Men and Women

et al. 2008

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Background: Coffee consumption has been associated with several risk factors for coronary heart disease, including increased cholesterol, increased blood pressure, and increased plasma total homocysteine (tHcy). tHcy is determined by several B-vitamins. However, reports about the association between coffee intake and B-vitamin status are few. Methods: We measured plasma B-vitamins and tHcy in a cohort of 10 601 healthy, middle-aged Norwegian men and women. Information about lifestyle factors, including coffee consumption, smoking, alcohol use, height, and weight, was obtained by interview. Results: Coffee consumption was dose-dependently associated with reduced plasma B-vitamin concentrations. Compared with coffee abstainers, individuals drinking ≥4 cups/day had 11.7% (P < 0.001), 14.1% (P < 0.001), and 5.5% (P = 0.01) lower plasma concentrations of folate, pyridoxal phosphate, and riboflavin, respectively, and the mean tHcy concentration was 6.8% (P < 0.001) higher. Quantile regression analysis showed essentially no difference in B-vitamin concentrations between coffee consumption categories at low vitamin concentrations but a progressive increase in the difference at higher concentrations. This pattern of differences (effect profile) was found independently of smoking status, alcohol intake, and sex. The decrease in folate explained approximately half of the increase in tHcy. Conclusions: Coffee consumption was associated with reduced circulating B-vitamin concentrations. The observed effect profiles indicated that coffee consumption preferentially affected the upper, but not the lower, part of the B-vitamin concentration distributions. We hypothesize that coffee consumption may increase the loss of surplus B-vitamins by excretion in urine.

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“…39,40 In the absence of evidence from randomized trials, however, several countries have been reluctant to recommend endoscopic screening procedures. Trials are currently underway in the United Kingdom, 41 Italy 42 and in Norway 43,44 to examine the efficacy of a single flexible sigmoidoscopy screen at around 60 years of age. 41,42 The efficacy of a 5-year screening interval is being examined in the US, 45 although it will be several years before data on colorectal cancer incidence and mortality become available.…”

Section: Sigmoidoscopymentioning

confidence: 99%

Balancing the ideal versus the practical—considerations of colorectal cancer prevention and screening

Lieberman

Atkin

2004

Aliment Pharmacol Ther

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SUMMARYColorectal cancer is responsible for over 500 000 deaths annually world-wide. Death from colorectal cancer is preventable, primarily through early diagnosis of disease that has not metastasized. The disease itself may be prevented by the detection and removal of colorectal adenomas, from which more than 95% of colorectal cancers arise. Currently there are several screening methods for the disease. These include faecal occult blood tests, sigmoidoscopy, barium enema and colonscopy as well as emerging methods of virtual colonoscopy and faecal DNA testing. While direct and indirect evidence support the efficacy of these tests they differ from each other in their sensitivity, specificity, cost, and safety. Various professional organizations in different geographical regions of the world have published recommendations on which screening methods to use and when in patients at average-or high-risk. The challenge in reducing the incidence and mortality of this disease lies in increasing accessibility to and compliance with screening and delivery within a quality assured programme.

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Design, Organization and Management of a Controlled Population Screening Study for Detection of Colorectal Neoplasia: Attendance Rates in the NORCCAP Study (Norwegian Colorectal Cancer Prevention)

Abstract: The present FSIFS&FOBT screening study obtained a high acceptance rate for both screening modalities. The attendance rate was stable throughout the trial, suggesting an acceptable model for management of future countrywide screening.

Cited by 87 publications

References 16 publications

Potential for Colorectal Cancer Prevention of Sigmoidoscopy Versus Colonoscopy: Population-Based Case Control Study

Potential for Colorectal Cancer Prevention of Sigmoidoscopy Versus Colonoscopy: Population-Based Case Control Study

Coffee Consumption and Circulating B-Vitamins in Healthy Middle-Aged Men and Women

Balancing the ideal versus the practical—considerations of colorectal cancer prevention and screening

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