Design, Performance Evaluation, and Modeling of an Ultrahigh Resolution Detector Dedicated for Simultaneous SPECT/MRI

Lai, Xiaochun; Cai, Liang; Tan, Jiawei; Zannoni, Elena; Odintsov, B. M.; Meng, Ling-Jian

doi:10.1109/trpms.2021.3053592

Cited by 4 publications

(3 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of course, the use of CZT detectors can provide advantages in terms of energy resolution and compactness (no need for liquid cooling). Very interesting results, in particular with MRI-compatible preclinical SPECT inserts with high spatial resolution, have been achieved [32]. Unfortunately, the potential for that technology to scale up to clinical systems has not yet been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Challenges in Acquiring Clinical Simultaneous SPECT-MRI on a PET-MRI Scanner

Morahan

D’Adda

Erlandsson

et al. 2023

IEEE Trans. Radiat. Plasma Med. Sci.

View full text Add to dashboard Cite

The INSERT is the world's first clinical SPECT-MRI brain imaging system based on scintillation detectors with a SiPM readout. Here we demonstrate its use within a clinical MRI environment for the first time. Using a standard transmit-receive head coil, and with an appropriate selection of a custom MRI sequence (GRE), we overcome mutual interference. The INSERT and its bulky 50 kg tungsten collimator introduce magnetic field inhomogeneity. Due to the specific MRI-compatible collimator design, inhomogeneity is compensated by shimming, leading to simultaneous acquisition. We process the SPECT data acquired alongside the MRI sequence to evaluate the SPECT system performance and the impact of the MRI. Finally, we present a set of simultaneous SPECT-MRI acquisitions, demonstrating multimodal imaging capabilities, albeit with a limited MRI sequence.

show abstract

Section: Discussionmentioning

confidence: 99%

Challenges in Acquiring Clinical Simultaneous SPECT-MRI on a PET-MRI Scanner

Morahan

D’Adda

Erlandsson

et al. 2023

IEEE Trans. Radiat. Plasma Med. Sci.

View full text Add to dashboard Cite

show abstract

“…While PET/MRI is nowadays well consolidated [10], SPECT/MRI is still a niche and our work aims at fostering its development toward clinical use. High resolution SPECT/MRI scanners based on CdTe were realized for preclinical imaging [11] with excellent spatial and energy resolution, but limited FoV. We have successfully demonstrated the first clinical simultaneous SPECT/MRI imaging for brain oncology.…”

Section: Simultaneous Spect-mrimentioning

confidence: 99%

First Simultaneous Acquisition of a Clinical SPECT-MRI Brain INSERT

Morahan,

D’Adda,

Erlandsson

et al. 2022

2022 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

View full text Add to dashboard Cite

“…Pixelated CdTe/CZT detectors have achieved excellent energy and spatial resolution and show great advantages for brain SPECT imaging [1], MRI compatible SPECT systems [2], clinical SPECT imaging [3], high spatial resolution PET imaging [4], and CT systems with multi-contrast imaging [5]. In nuclear medicine and molecular imaging applications, the imaging system performance is intrinsically determined by the accurate location and energy of single-photon interactions within the CdTe/CZT sensors.…”

Section: Introductionmentioning

confidence: 99%

Joint estimation of interaction position and energy deposition in semiconductor SPECT imaging sensors using fully connected neural network

2023

Self Cite

View full text Add to dashboard Cite

Objective: Pixelated semiconductor detectors such as CdTe and CZT sensors suffer spatial resolution and spectral performance degradation induced by charge-sharing effects. It is critical to enhance the detector property through recovering the energy-deposition and position estimation. Approach: In this work, we proposed a Fully-Connected-Neural-Network (FCNN)-based charge-sharing reconstruction algorithm to correct the charge-loss and estimate the sub-pixel position for every multi-pixel charge-sharing event. Main results: Evident energy resolution improvement can be observed by comparing the spectrum produced by a simple charge-sharing addition method and the proposed energy correction methods. We also demonstrate that sub-pixel resolution can be achieved in projections obtained with a small pinhole collimator and an innovative micro-ring collimator. Significance: These achievements are crucial for multiple-tracer SPECT imaging applications, and for other semiconductor detector-based imaging modalities.

show abstract

Design, Performance Evaluation, and Modeling of an Ultrahigh Resolution Detector Dedicated for Simultaneous SPECT/MRI

Cited by 4 publications

References 57 publications

Challenges in Acquiring Clinical Simultaneous SPECT-MRI on a PET-MRI Scanner

Challenges in Acquiring Clinical Simultaneous SPECT-MRI on a PET-MRI Scanner

First Simultaneous Acquisition of a Clinical SPECT-MRI Brain INSERT

Joint estimation of interaction position and energy deposition in semiconductor SPECT imaging sensors using fully connected neural network

Contact Info

Product

Resources

About