In the high-power laser device, through precisely positioning the target and pointing multiple laser beams at a very small area on the target surface, the laser power density coupled with the target can be greatly improved and is conducive to the research of laser-induced plasma experiments. This paper proposes a set of target positioning and laser beam pointing system, which has advantages of high experiment efficiency, high target positioning and laser pointing accuracy. This system can automatically correct the attitude and position of targets, and make all laser converge together by adjusting their incident directions. It was verified that the target positioning error is 14.83 µm and the beam guidance accuracy is 9.70 µm.