Design Simulation of a Rotating Dual-Headed PET/CT Scanner for Breast Imaging

Lamare, F.; Bowen, Samuel P.; Visvikis, Dimitris; Cortes, PC; Wu, Yue; Tran, V.H.; Boone, John M.; Cherry, Simon R.; Badawi, Ramsey D.

doi:10.1109/nssmic.2005.1596608

Cited by 16 publications

(12 citation statements)

References 8 publications

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“…2). For consistency with previous work [3], the distance from the base of the breast model to the top of the field of view was set to 2 cm. FDG uptake in the torso phantom was assumed normal and set to values measured by Ramos et al [1].…”

Section: B Patient Phantommentioning

confidence: 99%

“…5 shows NEC rates for the non-DOI cylindrical scanner, the DOI capable scanner, and our current prototype (the dual planar system with readout at the detector head level and PCIbased acquisition electronics). System parameters for the prototype are given by Lamare et al [3]. It can be seen that at 20 mCi injected dose, the cylindrical scanner generates an NEC of 32 kcps, compared to 21 kcps for the DOI scanner (Fig.…”

Section: A Comparison Ofnec Ratesfor All Scannersmentioning

confidence: 99%

“…The high out of field of view (FOV) activity and relatively low tumor to background uptake ratio associated with FDG dedicated breast PET imaging mandate a system that has a high geometrical sensitivity to trues, while at the same time being optimized for the wide variability in patient breast size [2,3]. Our current planar dual-head camera prototype was designed to be integrated with the dedicated pendant breast CT scanner constructed by Boone et al [4,5], and achieves maximal sensitivity for a given breast by varying the separation distance between heads.…”

Section: Introductionmentioning

confidence: 99%

“…Our current planar dual-head camera prototype was designed to be integrated with the dedicated pendant breast CT scanner constructed by Boone et al [4,5], and achieves maximal sensitivity for a given breast by varying the separation distance between heads. Previous Monte Carlo simulations performed with this system in a patient imaging scenario revealed that the scanner produces significantly lower NEC rates at viable injection activities (-5 to 20 mCi) when compared to whole body (WB) PET, and this result can be partially accounted for by the relatively high singles-to-trues ratio (-300:1 compared to -100:1 for WB PET) and low trues rate [3].…”

Section: Introductionmentioning

confidence: 99%

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Monte Carlo Simulation Study of Several Camera Designs for the PET Component of a Dedicated Breast PET/CT Scanner

Bowen¹,

Yang²,

Wu³

et al. 2006

2006 IEEE Nuclear Science Symposium Conference Record

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In this study we used Monte Carlo simulations to analyze the patient imaging performance of a range of camera geometries for the PET portion of a dedicated pendant breast PET/CT system. Performance was assessed by comparing NEC, rates, and scatter fractions for a range of injected FDG activities. The same LSO block detector (9x9 arrays of 3 mm x 3 mm x 20 mm crystals and 3.3 mm pitch) was used to compose a cylindrical, split-ring, five-sided box, and a planar dual-headed system. To simulate the patient an anthropomorphic model was created consisting of the NCAT phantom, volumes acting as the brain and bladder, and one of three CT-derived pendant breast shapes (representative of small, medium, and large volume breasts) appended to the left chest wall, with FDG concentration ratios set to those given by Ramos et al. Systems were modeled with LSO background, dead time effects (256 ns paralysable at the block level, and non-paralysable), a 7.5 ns coincidence time window, and energy window of 350 to 650 keV. The cylindrical scanner gave significantly higher NEC rates across all viable injection activities (-5 to -20 mCi) regardless of the breast size imaged. For the medium sized breast, at an injection activity of 20 mCi, the cylindrical scanner showed a 3-fold gain in NEC rate compared to the dual-headed system (32.4 vs. 10.5 kcps) at the cost of a slightly higher scatter fraction (0.28 vs. 0.24). Additional simulations with an alternative cylindrical scanner system composed of DOI capable detectors (APD front end and PMT back) gave somewhat lower NEC rates compared with the conventional cylindrical design due to a lower effective packing fraction. Based on these results the cylindrical scanner was found the optimal geometry for prone dedicated breast PET/CT imaging.

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Section: B Patient Phantommentioning

confidence: 99%

Section: A Comparison Ofnec Ratesfor All Scannersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Monte Carlo Simulation Study of Several Camera Designs for the PET Component of a Dedicated Breast PET/CT Scanner

Bowen¹,

Yang²,

Wu³

et al. 2006

2006 IEEE Nuclear Science Symposium Conference Record

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“…3,4 However, special considerations on detector design and system architecture need to be taken into account given the demands for high spatial resolution and high photon sensitivity in order to detect early stages of breast cancer, which cannot be satisfied with the current clinical tomograph designs. [5][6][7][8][9] Breast-dedicated PET systems have recently demonstrated their clinical relevance, 10 whereas specialized system designs may be used to improve system performance. 11 Our group is developing a 1 mm 3 resolution PET scanner dedicated to breast imaging.…”

Section: Introductionmentioning

confidence: 99%

Physical effects of mechanical design parameters on photon sensitivity and spatial resolution performance of a breast‐dedicated PET system

et al. 2010

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Purpose: This study aims to address design considerations of a high resolution, high sensitivity positron emission tomography scanner dedicated to breast imaging. Methods: The methodology uses a detailed Monte Carlo model of the system structures to obtain a quantitative evaluation of several performance parameters. Special focus was given to the effect of dense mechanical structures designed to provide mechanical robustness and thermal regulation to the minuscule and temperature sensitive detectors. Results: For the energies of interest around the photopeak ͑450-700 keV energy window͒, the simulation results predict a 6.5% reduction in the single photon detection efficiency and a 12.5% reduction in the coincidence photon detection efficiency in the case that the mechanical structures are interspersed between the detectors. However for lower energies, a substantial increase in the number of detected events ͑approximately 14% and 7% for singles at a 100-200 keV energy window and coincidences at a lower energy threshold of 100 keV, respectively͒ was observed with the presence of these structures due to backscatter. The number of photon events that involve multiple interactions in various crystal elements is also affected by the presence of the structures. For photon events involving multiple interactions among various crystal elements, the coincidence photon sensitivity is reduced by as much as 20% for a point source at the center of the field of view. There is no observable effect on the intrinsic and the reconstructed spatial resolution and spatial resolution uniformity. Conclusions: Mechanical structures can have a considerable effect on system sensitivity, especially for systems processing multi-interaction photon events. This effect, however, does not impact the spatial resolution. Various mechanical structure designs are currently under evaluation in order to achieve optimum trade-off between temperature stability, accurate detector positioning, and minimum influence on system performance.

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High-Resolution and Animal Imaging Instrumentation and Techniques

Belcari¹,

Guerra²,

Panetta³

2020

Handbook of Particle Detection and Imaging

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During the last two decades, we have observed a growing interest in in vivo imaging techniques for small animals. This is due to the necessity of studying biochemical processes at a molecular level for pharmacology, genetic, and pathology investigations. This field of research is usually called "molecular imaging."Advances in biological understanding have been accompanied by technological advances in instrumentation and techniques and image reconstruction software, resulting in improved image quality, visibility, and interpretation. The main technological challenge is then the design of systems with high spatial resolution and high sensitivity.This chapter gives a short overview of the state-of-the-art technologies for high-resolution and high-sensitivity molecular imaging techniques, namely, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) as well as small animal x-ray computed tomography (CT). Multimodality techniques, namely, PET/CT, PET/MR, and SPECT/MR, merging molecular information with anatomical details are also introduced. Finally, the new trends in detector technology for other high-resolution applications like breast cancer investigation are presented.

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Design Simulation of a Rotating Dual-Headed PET/CT Scanner for Breast Imaging

Cited by 16 publications

References 8 publications

Monte Carlo Simulation Study of Several Camera Designs for the PET Component of a Dedicated Breast PET/CT Scanner

Monte Carlo Simulation Study of Several Camera Designs for the PET Component of a Dedicated Breast PET/CT Scanner

Physical effects of mechanical design parameters on photon sensitivity and spatial resolution performance of a breast‐dedicated PET system

High-Resolution and Animal Imaging Instrumentation and Techniques

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