A novel 2.45 GHz self-adaptive rectifier with high efficiency and a wide input power range is proposed in this paper. It consists of a high-power sub-rectifier branch, a low-power sub-rectifier branch, an impedance transform and isolation network (ITIN), and a feedback network. Impedance matching is realized by ITIN for both branches. The proposed design is able to switch between these two branches by the feedback network according to its output voltage level. The rectifier has been simulated, fabricated, and tested. The measured power conversion efficiency (PCE) exceeds 50% over the input power range from 5 to 29 dBm, with a total dynamic range of 24 dB. The input range when PCE exceeds 60% is from 10 dBm to 28 dBm. The maximum efficiency is 75.2% at 26 dBm input power.