Design strategy and recent progress of fluorescent probe for noble metal ions (Ag, Au, Pd, and Pt)

She, Mengyao; Wang, Zhaohui; Chen, Jiao; Li, Quanquan; Liu, Ping; Chen, Fulin; Zhang, Shengyong; Li, Jianli

doi:10.1016/j.ccr.2020.213712

Cited by 60 publications

(21 citation statements)

References 332 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The palladium could subsequently bind with thiol-containing proteins, nucleic acids and other biomacromolecules to disturb their normal physiological function and endanger human health. 161–163 Therefore, the residual palladium concentration in the environment needs to be detected in real time. Lin's group synthesized a propargyl ether decorated hemicyanine fluorophore NIR-Pd-1 for monitoring palladium (Fig.…”

Section: Nir Fluorescent Probes For Ionic Speciesmentioning

confidence: 99%

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Nir Fluorescent Probes For Ionic Speciesmentioning

confidence: 99%

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

et al. 2022

View full text Add to dashboard Cite

show abstract

“…by virtue of their strong coordinating abilities with electronegative heteroatoms (N, O, S, etc. ). ,,− Common principles available for this purpose are based on (1) suitable ring/cavity size for a prescribed ions, such as crown ethers with various ring sizes for alkali and alkaline earth metal ions; (2) applicable ligands for easily generation of five- or six-membered ring complexes with metal ions, such as ethylene glycol tetraacetic acid moiety for Ca 2+ ; and (3) soft/hard acid base theory, such as the soft sulfur-containing receptors with high affinity for soft metal ions (e.g., Hg 2+ ). On the other hand, for design of such probes, a photophysical process, like PET, and ICT should be incorporated to translate analytes binding into a spectroscopic signal change.…”

Section: Activatable Pa Probes For Molecular Detectionmentioning

confidence: 99%

Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

et al. 2022

View full text Add to dashboard Cite

Photoacoustic (PA) imaging technology, a three-dimensional hybrid imaging modality that integrates the advantage of optical and acoustic imaging, has great application prospects in molecular imaging due to its high imaging depth and resolution. To endow PA imaging with the ability for real-time molecular visualization and precise biomedical diagnosis, numerous activatable molecular PA probes which can specifically alter their PA intensities upon reacting with the targets or biological events of interest have been developed. This review highlights the recent developments of activatable PA probes for precise biomedical applications including molecular detection of the biotargets and imaging of the biological events. First, the generation mechanism of PA signals will be given, followed by a brief introduction to contrast agents used for PA probe design. Then we will particularly summarize the general design principles for the alteration of PA signals and activatable strategies for developing precise PA probes. Furthermore, we will give a detailed discussion of activatable PA probes in molecular detection and biomedical imaging applications in living systems. At last, the current challenges and outlooks of future PA probes will be discussed. We hope that this review will stimulate new ideas to explore the potentials of activatable PA probes for precise biomedical applications in the future.

show abstract

“…Inspired by the pioneering work of Alexander L. Antaris et al, certain building blocks have created NIR-II fluorophores. [17] One of the most common methods include exploiting benzo[1,2-c:4,5-c']bis( [1,2,5]thiadiazole) (BBTD) as an electron acceptor core attached to thiophene, triphenylamine, and their derivatives. In addition, upon binding with the aryl group, the cyano group could induce intermolecular electron transfer to ensure the emission of NIR-II fluorescence.…”

Section: D-a Systemmentioning

confidence: 99%

“…[1][2][3] Among numerous imaging methods, fluorescence-based imaging methods enable scientists to uniquely visualize and interpret biological events, which act as a direct, easy-operative, and noninvasive approach for studying life sciences. [4][5][6] Conventional fluorescence imaging methods exploit fluorescence in the visible (400-650 nm) and the first near-infrared window (NIR-I) regions (650−950 nm), which exhibit defects of relatively low tissue penetration, unavoidable tissue absorption and scattering, and undesired autofluorescence that deteriorate the imaging efficacy. [7][8][9] Thus, to reduce these adverse factors, fluorescence imaging in the second near-infrared (NIR-II) region (1000-1700 nm)…”

Section: Introductionmentioning

confidence: 99%

Rational Modulation Strategies to Improve Bioimaging Applications for Organic NIR‐II Fluorophores

Wang

She

Chen

et al. 2021

Advanced Optical Materials

Self Cite

View full text Add to dashboard Cite

with optical simulation and empirical derivation is considered as "biologicalappropriate". [10,11] In addition, the autofluorescence intensity, effective attenuation coefficient, and scattering coefficient of biological components are significantly minimized in the NIR-II region (Figure 1). [12,13] Initially, Kevin Welsher et al. reported that the most prominent advantage of the reduced adverse factors is a deeper penetration depth beyond 1 µm by exploiting single-walled carbon nanotubes (SWNTs). [14] However, Smith et al. highlighted that the nonbiodegradable nature and needle-like structure of SWNTs can cause tissue damage and chronic toxicity. [12] Moreover, optical bioimaging in clinical applications employs small fluorescent molecules as imaging agents. [4] Consequently, current research progressively focuses on the relatively compact and minimally toxic nature of organic fluorophores that can be observed in NIR-II fluorescence imaging.Based on the development of organic NIR-II fluorophores, construction and modification are considered as two essential parts of interest. As diverse synthetic methods enable the combination of functional building blocks for facilitating NIR-II fluorescence, the modulation is vital for developing NIR-II fluorescence imaging. Although the biosafety of organic NIR-II fluorophores is a major concern, its advantages can be completely exploited based on its biocompatibility. [4,17,18] Therefore, the bioapplication of organic NIR-II fluorophores can be simultaneously enriched. An additional issue pertains to the unsatisfactory fluorescence quantum yield (QY) of organic NIR-II fluorophores. The simultaneous regulation of the ground and excited states promotes the easy-to-be-quenched property of organic NIR-II fluorophores, which adversely affects the fluorescence QY. [19,20] Moreover, the activatable properties exhibited by organic NIR-II fluorophores are related to modulation to induce a smarter signal output model rather than the "always ON" type.This study reviews the construction of organic NIR-II fluorophores in various molecular types (e.g., donor-acceptor (D-A) type, organic small molecules with π-conjugation systems, and organic polymers with π-conjugation systems). In addition, the modulation strategies for improving biosafety, fluorescence QY, biotargeting ability, and signal activatable features are summarized as well. Furthermore, this study highlights the current limitations that should be addressed in depth, including the future direction of the modulation strategy for the development of organic NIR-II fluorophores.The second near-infrared (NIR-II) window is highly effective in fluorescent bioimaging to obtain a deep view of living systems. Among numerous NIR-II fluorescent agents, organic fluorophores have been considered as ideal candidates in this field. Thus, modulation strategies should be considered to improve the performance and functionality of such agents. This review provides an overview of the development and construction of organic NIR-II fluorophores. More i...

show abstract

Design strategy and recent progress of fluorescent probe for noble metal ions (Ag, Au, Pd, and Pt)

Cited by 60 publications

References 332 publications

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

Rational Modulation Strategies to Improve Bioimaging Applications for Organic NIR‐II Fluorophores

Contact Info

Product

Resources

About