Design Study of a Novel Positron Emission Tomography System for Plant Imaging

Antonecchia, Emanuele; Bäcker, Markus; Cafolla, Daniele; Ciardiello, Mariachiara; Kühl, Charlotte; Pagnani, Giancarlo; Wang, Jiale; Wang, Shuai; Zhou, Feng; D’Ascenzo, N.; Gialanella, L.; Pisante, Michele; Rose, Georg; Xie, Qingguo

doi:10.3389/fpls.2021.736221

Cited by 9 publications

(5 citation statements)

References 56 publications

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“…Additionally, the majority of these PET systems did not employ full ring configurations, but instead used partial ring geometries [16][17][18]. This choice may have been influenced by the cost and complexity of electronics associated with fully ring-shaped PET systems, although there has been research on a new PET system for plant research designed and evaluated through simulation [19].…”

Section: Introductionmentioning

confidence: 99%

A large field-of-view angled panel detector for the development of a plant PET system

Yamamoto,

Watabe,

Yamaguchi

et al. 2024

J. Inst.

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In plant research, positron emission tomography (PET) is sometimes employed for physiological studies of plants. However, due to the generally high cost of PET systems, their application in plant research centers can be challenging. Furthermore, the configurations of commercial PET systems might not always align well with the requirements of plant research. To address these issues, we have taken the initial steps towards a solution by developing a large field-of-view (LFOV) angled panel detector intended for the development of a plant PET system. This panel detector is composed of two gadolinium orthosilicate (GSO) scintillator blocks, an angled light guide, and four flat panel photomultiplier tubes (FP-PMTs). The GSO pixel size used in the scintillator block measures 2.65 mm (radial)× 2.85 mm (axial)× 15.0 mm, arranged in a configuration of 16 (radial)× 32 (axial) to form a scintillator block with overall dimensions of 44.0 mm (radial)× 94.4 mm (axial)× 15 mm (depth). By implementing an angled light guide, the two scintillator blocks were positioned at a 22.5-degree angle, resulting in the creation of a LFOV angled panel detector. This specific angle allowed for the arrangement of 16 scintillator blocks in a hexadecagonal shape using 8 panel detectors when arranged in a circular configuration. We successfully constructed a panel detector with an approximate field-of-view of 10 cm× 10 cm and conducted a comprehensive performance evaluation. Upon irradiating the panel detector with 511 keV gamma photons, nearly all 1024 GSO pixels were accurately resolved in the position histogram, displaying minimal distortion, and exhibiting an average peak-to-valley ratio of 5.0. Additionally, the energy resolution achieved was 14% full width at half maximum (FWHM). The resulting LFOV angled panel detector holds considerable promise for the use within a cost-effective, user-friendly as well as high performance plant PET system.

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Section: Introductionmentioning

confidence: 99%

A large field-of-view angled panel detector for the development of a plant PET system

Yamamoto,

Watabe,

Yamaguchi

et al. 2024

J. Inst.

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show abstract

“…While there have been some ring PET systems [15][16][17][18], the majority did not employ full ring configurations, opting for partial ring geometries [16][17][18]. Although there has been research on a new PET system for plant research designed and evaluated through simulation [19], an entirely new, ring-shaped PET system optimized for plants, that enables three-dimensional imaging and is cost-effective as well as user-friendly in imaging of plants, has not been realized yet. Very recently, a PET system specifically designed for plants has been reported [20], but the concept differs from our cost-effective PET system.…”

Section: Introductionmentioning

confidence: 99%

Construction and initial performance evaluation of a newly developed plant PET system

Yamamoto,

Watabe,

Yamaguchi

et al. 2024

J. Inst.

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In plant research, positron emission tomography (PET) is occasionally employed for physiological studies, offering valuable insights. However, the generally high cost of PET systems and their suboptimal design for plant research pose challenges to their application in this field. To address these issues, we have developed a new PET system optimized specifically for plant research. The PET detector ring was positioned vertically to enable measurements of plants in their normal upright position. The developed plant PET system features a transaxial field of view (FOV) of approximately 12 cm and an axial FOV slightly larger than 9 cm, allowing for the imaging of relatively small-sized plants. To facilitate imaging of taller plants, the PET system can expand the axial FOV by changing the subject height using a lab jack, enabling the imaging of taller plant species. The measured spatial resolution at the central FOV was 3.3 mm FWHM, and the sensitivity was 3.7%. The timing resolution was 6.78 ns FWHM with a lower energy threshold set to 350 keV. Phantom images simulating plants were successfully measured using the developed plant PET system. We conclude that the developed plant PET system holds promise for effective plant imaging.

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“…Another novel configuration was also introduced for plant imaging, which extends with a vertical FOV. In order to make imaging possible for different size plants, they assumed two moveable half-cylinders that can be separated at a distance up to 40 mm (Antonecchia et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Active-PET: a multifunctional PET scanner with dynamic gantry size featuring high-resolution and high-sensitivity imaging: a Monte Carlo simulation study

et al. 2022

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Organ-specific PET scanners have been developed to provide both high spatial resolution and sensitivity, although the deployment of several dedicated PET scanners at the same center is costly and space-consuming. Active-PET is a multifunctional PET scanner design exploiting the advantages of two different types of detectors modules and mechanical arms mechanism enabling to reposition the detectors to allow the implementation of different geometries/configurations. Active-PET can be used for different applications, including brain, axilla, breast, prostate, whole-body, preclinical and pediatrics imaging, cell tracking, and image guidance for therapy. Monte Carlo techniques were used to simulate a PET scanner with two sets of high resolution and high sensitivity pixelated Lutetium Oxyorthoscilicate (LSO(Ce)) detector blocks (24 for each group, overall 48 detector modules for each ring), one with large pixel size (4×4 mm2) and crystal thickness (20 mm), and another one with small pixel size (2×2 mm2) and thickness (10 mm). Each row of detector modules is connected to a linear motor that can displace the detectors forward and backward along the radial axis to achieve variable gantry diameter in order to image the target subject at the optimal/desired resolution and/or sensitivity. At the center of the field-of-view, the highest sensitivity (15.98 kcps/MBq) was achieved by the scanner with a small gantry and high-sensitivity detectors while the best spatial resolution was obtained by the scanner with a small gantry and high-resolution detectors (2.2 mm, 2.3 mm, 2.5 mm FWHM for tangential, radial, and axial, respectively). The configuration with large-bore (combination of high-resolution and high-sensitivity detectors) achieved better performance and provided higher image quality compared to the Biograph mCT as reflected by the 3D Hoffman brain phantom simulation study. We introduced the concept of a non-static PET scanner capable of switching between large and small field-of-view as well as high-resolution and high-sensitivity imaging.

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Design Study of a Novel Positron Emission Tomography System for Plant Imaging

Cited by 9 publications

References 56 publications

A large field-of-view angled panel detector for the development of a plant PET system

A large field-of-view angled panel detector for the development of a plant PET system

Construction and initial performance evaluation of a newly developed plant PET system

Active-PET: a multifunctional PET scanner with dynamic gantry size featuring high-resolution and high-sensitivity imaging: a Monte Carlo simulation study

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