Design, syntheses, characterization, and cytotoxicity studies of novel heterobinuclear oxindolimine copper(II)-platinum(II) complexes

Synthesis, Characterization, and Biological Evaluation of Unimetallic and Heterobimetallic Complexes of Bivalent Copper

“…Their square planar geometry has also been verified from electronic spectra. However, in case of heterobimetallic complexes, g ┴ > g ‖ is observed thereby proposing a distorted octahedral geometry with d z 2 as the ground state of the system [ 25 ]. On this basis, it is decided that chloride ions coordinate with Cu(II) on complexation with organometallic dichlorides in case of heterobimetallic complexes thus achieving an octahedral environment for copper in these complexes.…”

In Vitro Anticancer Activity of Nanoformulated Mono‐ and Di‐nuclear Pt Compounds

“…Nanoformulations of 1-4 exhibited obvious cytotoxicity (20 h) against melanoma cells (Figure 3) with IC 50 of 5.32 μM (1, Figures 3a and 3b), 0.87 μM (2, Figures 3c and 3d), 11.23 μM (3, Figures 3e and 3 f), and 2.82 μM (4, Figures 3g and 3 h). These values are comparable to that of cisplatin (7.4 μM, 24 h), [36] Pt-Pyrazole complexes [Pt(PzÀ CH 3 ) 2 Cl 2 ] (8.3 μM, 72 h), [37] [Pt-(PzÀ F) 2 Cl 2 ] (17.7 μM, 72 h), [37] PtÀ Cu heterometallic cluster [CuCl (isad)Pt(NH 3 )Cl 2 ] (0.63 μM, 24 h), [38] β-cyclodextrin encapsulated trans-dichloro-(dipyridine)platinum(II) (0.71 μM, 20 h), [39] and cisplatin human serum albumin nanoparticles (150 μM, 24 h). [40] It is interesting to note that dinuclear cluster 2 exhibited the lowest IC 50 value, indicating that the presence of S atoms in the cluster might play a non-innocent role (e. g. as a convenient leaving group).…”

Heterometallic Multinuclear Complexes as Anti‐Cancer Agents‐An Overview of Recent Developments

“…Da Costa Ferreira and colleagues investigated the unusual combination of platinum(II) and copper(II) metal centres with oxindolimine ligands (Figure ). The copper was included so as to provide an alternative mode of action, as it has been shown to induce ROS generation and inhibition of topoisomerase 1B and cyclin‐dependent kinases . The inclusion of the two different metals showed a cooperative effect by enhancing the anti‐cancer activity beyond that of the individual monometallic fragments.…”

“…The platinum‐copper complexes investigated by Da Costa Ferreira and colleagues . The IC 50 (µM) values reported are shown below the chemical structures.…”