Proceedings of the 1st Molecules Medicinal Chemistry Symposium, Barcelona, Spain 2017
DOI: 10.3390/proceedings1060662
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Design, Synthesis and Activity of New Polymyxins

Abstract: Antibiotic resistance is a daunting challenge for public health systems worldwide. A major goal to fight resistant bacteria involves the design, discovery and development of new antibiotics, particularly against multi-drug-resistant strains. Currently, there is renewed interest in polymyxins, an old class of antimicrobial cyclic lipopeptides, highly potent against therapeutically relevant Gramnegative bacteria. Polymyxins are now used as last resort antibiotics in hospitals because of their nephrotoxicity and … Show more

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