Design, synthesis, and antibacterial activity of novel Schiff base derivatives of quinazolin-4(3H)-one

Synthesis, Cytotoxic, and Antibacterial Evaluation of Quinazolinone Derivatives with Substituted Amino Moiety

“…Wang et al . synthesized novel imine derivatives of quinazolin‐4(3 H )‐one, and demonstrated that compound S3 exhibited stronger antibacterial activities against tobacco and tomato bacterial wilts compared with the commercial plant bactericide thiodiazole copper . Arora et al .…”

“…[12] Wang et al synthesized novel imine derivatives of quinazolin-4(3H)-one, and demonstrated that compound S3 exhibited stronger antibacterial activities against tobacco and tomato bacterial wilts compared with the commercial plant bactericide thiodiazole copper. [27] Arora et al synthesized several quinazolinone derivatives with a Schiff base nucleus, and discovered that compounds S4 and S5 emerged as broad spectrum antibacterial agents whereas S6 -S9 showed broad spectrum antifungal properties. [28] Noolvi and Patel synthesized a novel series of 3-(substituted benzylideneamino)-7-chloro-2phenyl quinazoline-4(3H)-ones and tested for their anticancer activity, among them, compound S10 showed remarkable activity against CNS SNB-75 cancer cell line.…”

Synthesis and Antimicrobial Activities of Novel 1,2,4-Triazole-acyl-hydrazone Derivatives Containing the Quinazolin-4-one Moiety

“…此外, 酰腙类化合物由于分子结构中含有活性亚结构基团 (CONHN＝CH)也表现出良好的抗菌 [13] 和杀虫 [14] 等活 性 , 商品化药剂 有醌肟腙( Benqu inox)和呋喃 唑酮 (Furazolidone). 另一方面, 喹唑啉-4-酮是一类广谱的药 效基团, 具有多种优良生物活性, 如抗细菌 [15] 、抗真 菌 [16] 、抗肿瘤 [17] 和抗病毒 [18] 等, 已商品化的喹唑啉酮类 杀 菌 剂 有 氟 喹 唑 ( F l u q u i n c o n a z o l e ) 和 阿 巴 康 唑 (Albaconazole). 以往的研究表明在同一分子中引入结 构不同的抗菌活性片段, 有可能筛选出抗菌活性更高、 抗菌谱更广的化合物 [19,20] .…”

Design, Synthesis and Biological Activities of Novel Quinazolinone Derivatives Bearing 4-Phenyl-5-thioxo-1,2,4-triazole Mannich Bases

“…喹唑啉酮类衍生物具有优良的生物活性, 已在医药 和农药领域得到了广泛的应用, 如抗肿瘤 [1] 、抗细菌 [2] 、 抗真菌 [3] 、抗疟 [4] 、抗病毒 [5] 等. 目前已商品化的喹唑啉 酮类药物有杀菌剂氟喹唑、抗寄生虫药常山酮、镇静药 物安眠酮和抗癌药物诺拉曲特(图 1)等.…”