Design, Synthesis, and Antifungal Evaluation of Novel Cuminic Acid Derivatives as Potential Laccase Inhibitors
Zihui Yang,
Yigui Qiu,
Daojun Jin
et al.
Abstract:In search of novel natural product-based fungicides, 49 cuminic acid derivatives were designed, synthesized, and screened for their in vitro antifungal effects toward seven phytopathogenic fungi and oomycetes. Consequently, several derivatives exhibited strong antifungal activities toward Fusarium graminearum, Botryosphaeria dothidea, and Valsa mali. Among them, compound 2b exhibited the most potent antifungal activity toward B. dothidea (EC 50 = 0.96 mg/L), more powerful than chlorothalonil. The in vivo assay… Show more
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