Design, synthesis and antimicrobial activity evaluation of novel tetrahydrocarbazole derivatives against phytopathogenic fungi and bacteria
Yan‐Yan Ding,
Tian‐Li Dai,
Xiong‐Fei Luo
et al.
Abstract:BackgroundPlant pathogenic bacteria and fungi had a wide impact on various crops and caused serious economic losses. Compared to traditional antibiotics and fungicides, alkaloids are noteworthy for their significant biological activities. Tetrahydrocarbazole (THCz) was widely present in many indole alkaloids and had various pharmacological activities. This study used Fischer indole synthesis method and fragment splicing strategy to design and synthesize a novel drug like chemical entity based on THCz alkaloid … Show more
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