Design, Synthesis and Antimicrobial Studies of 5-Benzylidene Substituted Rhodanine Containing Heterocycles

Abstract

Objective: The principal objective of the study was to synthesize and evaluate the biological activities of a novel class of 5-benzylidene substituted rhodanine derivatives as antimicrobial agents.
 Methods: All the synthesized compounds (D1-D10) were screened for their antimicrobial activities using microdilution methods as per the reported procedure. All compounds were evaluated as potential antimicrobial agents against gram-positive bacteria: Bacillus cereus, Staphylococcus aureus, gram negative bacteria: Escherichia coli Pseudomonas aeruginosa and Klebsiella pneumoniae Fungal cultures used in the study were Aspergillus niger, Candida albicans, Candida parapsilosis, Candida tropicalis and Candida glabrata.
 Results: Compound D6 showed good antifungal activity in the MIC range 16μg/ml against Candida tropicalis and Compound D10 showed good antifungal activity in the MIC range 16μg/ml against Candida glabrata. Compounds D2 and D5 showed good antibacterial activity at 32μg/ml. all the other compounds showed moderate antibacterial activity.
 Conclusion: Based on the above results, it can be concluded that the compounds may lead to the development of more potent antimicrobial drug candidates in the near future.

Antioxidant, Anticancer and Molecular Docking Studiesof Novel 5-Benzylidene Substituted Rhodanine Derivatives

“…thioxothiazolidinone by substituting various benzylidene derivatives at the 5 th position (Scheme 1) was reported previously [20]. Different Rhodanine derivatives (3a-3j) synthesized are given in table 1.…”

Optimization and Characterization of Essential Oils Formulation for Enhanced Stability and Drug Delivery System of Mefloquine

“…It was established that mefloquine is soluble in a variety of oils (Pomegranate oil, Black cumin seed oil, Garlic oil), surfactants (including Tween® 20, Tween® 80, Cremophore EL, Brij 35) 2 ml of each oil were placed in screw-capped glass vials with an excess amount of mefloquine added, and the mixture was constantly stirred for 2 min with a magnetic stirrer (REMI 1 MLH) [16]. The mixes were then agitated (100 rpm) in an orbital shaker (REMI-BL) for 72 h at 25 0.5 °C, then allowed to stabilize for 24 h. The REMI C-24 BL was used to extract the samples and centrifuge them for 30 min at 5000 rpm [26]. The supernatant solution was filtered using a millipore membrane filter (0.45 m), and it was then properly diluted using a 50:50 methanol-to-water system.…”