Design, synthesis and antiproliferative screening of newly synthesized acrylate derivatives as potential anticancer agents

Abstract

A sequence of novel acrylic acids and acrylic esters has been synthesized and evaluated for in vitro cytotoxicity against MCF-7 breast cancer cells.

Synthesis and biological research of new imidazolone-sulphonamide-pyrimidine hybrids as potential EGFR-TK inhibitors and apoptosis-inducing agents

“…In the initial step appropriate hippuric acid 2a,b was obtained by stirring appropriate aroyl chloride 1a,b and glycine in an aqueous sodium hydroxide solution, which was then heated in acetic anhydride at 80 °C to obtain active oxazolone compound 3a,b. 32 This was followed by condensation with suitable aryl aldehyde in the presence of anhydrous pyridine furnished the key intermediate 4-arylidene oxazolone compound 4a,b. 33 Refluxing acetic acid suspension of appropriate 4-arylidene oxazolone compound 4a,b with sulfadiazine in the existence of freshly melted sodium acetate afforded the titled compound 5a–l and 6a,b.…”

Design, synthesis and antiproliferative screening of newly synthesized coumarin-acrylamide hybrids as potential cytotoxic and apoptosis inducing agents

“…Most cytotoxic pharmaceuticals are known to have an antiproliferative impact by interrupting the cellular cycle at certain phase points. 31 To characterize the growth inhibition induced by the coumarin-acrylamide hybrids, we examined the impact of the most potent coumarin-aryl acrylamide hybrid 6e on cell cycle advancement in order to define the point at which the stoppage of cell cycle arrest develops in HepG2 cells. The impact on cell cycle distribution was assessed by a DNA flow cytometric analysis, upon incubation of HepG2 cells with coumarin-acrylamide hybrid 6e at the IC 50 concentration for 48 h. As shown in the results in Fig.…”

Design, Synthesis, and Biological Evaluation of Newly Synthesized Cinnamide-Fluorinated Containing Compounds as Bioactive Anticancer Agents

“…Continuing our investigations on the preparation of newer bioactive compounds with active biological properties on human cancerous cell lines, − we have synthesized cinnamide-fluorinated compounds 2a–7 in 60–76% yield (Figure ). The cytotoxic effects of these compounds on liver cancer HepG2 cell line were evaluated.…”