Design, synthesis, and antiproliferative screening of new quinoline derivatives bearing a <i>cis</i>-vinyl triamide motif as apoptosis activators and EGFR-TK inhibitors

Abd El-Lateef, Hany M.; Ahmed Gaafar, Ahmed Gaafar; Alqahtani, Arwa Sultan; Al-Mutairi, Aamal A.; Alshaya, Dalal Sulaiman; Elsaid, Fahmy Gad; Fayad, Eman; Farouk, N. A.

doi:10.1039/d4ra04915b

RSC Adv.

2024

DOI: 10.1039/d4ra04915b

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Design, synthesis, and antiproliferative screening of new quinoline derivatives bearing a cis-vinyl triamide motif as apoptosis activators and EGFR-TK inhibitors

Hany M. Abd El-Lateef,

Ahmed Gaafar Ahmed Gaafar,

Arwa Sultan Alqahtani

et al.

Abstract: A set of novel quinoline tethered cis-vinyl triamides derivatives has been designed, synthesized and screened for in vitro cytotoxicity against the MCF-7 breast adenocarcinoma cell line.

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Cited by 2 publications

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Novel quinolin-4-ylcarbonylhydrazine having N-(3-arylacryloyl) moiety: Design, synthesis and biological evaluation as potential cytotoxic agents against MDA-MB-231 via tubulin assembly inhibition

Abd El-Lateef,

Alharbi,

Fayad

et al. 2025

Journal of Molecular Structure

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Novel quinolin-4-ylcarbonylhydrazine having N-(3-arylacryloyl) moiety: Design, synthesis and biological evaluation as potential cytotoxic agents against MDA-MB-231 via tubulin assembly inhibition

Abd El-Lateef,

Alharbi,

Fayad

et al. 2025

Journal of Molecular Structure

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Design and synthesis of novel 2-(2-(4-bromophenyl)quinolin-4-yl)-1,3,4-oxadiazole derivatives as anticancer and antimicrobial candidates: in vitro and in silico studies

Ryad,

Elmaaty,

Selim

et al. 2024

RSC Adv.

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Design, synthesis, and antiproliferative screening of new quinoline derivatives bearing a cis-vinyl triamide motif as apoptosis activators and EGFR-TK inhibitors

Abstract: A set of novel quinoline tethered cis-vinyl triamides derivatives has been designed, synthesized and screened for in vitro cytotoxicity against the MCF-7 breast adenocarcinoma cell line.

Cited by 2 publications

References 54 publications

Novel quinolin-4-ylcarbonylhydrazine having N-(3-arylacryloyl) moiety: Design, synthesis and biological evaluation as potential cytotoxic agents against MDA-MB-231 via tubulin assembly inhibition

Novel quinolin-4-ylcarbonylhydrazine having N-(3-arylacryloyl) moiety: Design, synthesis and biological evaluation as potential cytotoxic agents against MDA-MB-231 via tubulin assembly inhibition

Design and synthesis of novel 2-(2-(4-bromophenyl)quinolin-4-yl)-1,3,4-oxadiazole derivatives as anticancer and antimicrobial candidates: in vitro and in silico studies

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