Design, Synthesis and Antiviral Activity Studies of Schizonepetin Derivatives

Bao, Beihua; Zheng, Meng; Li, Nian‐Guang; Meng, Zhengjie; Zhang, Li; Cao, Yudan; Yao, Weifeng; Shan, Mingqiu; Ding, Anwei

doi:10.3390/ijms140817193

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…VZV-associated diseases can be effectively treated with nucleoside analogs such as acyclovir (ACV) and famciclovir, which inhibit viral DNA synthesis [7,9]. However, the effectiveness of these drugs to treat VZV infections in immunocompromised and in immunodeficient patients is limited due to the development of resistant VZV strains [7,10]. In addition, ACV and other available nucleoside analogs have different undesired side effects (like nausea, vomiting, headache and others) [11], and are not highly effective against reactivated herpes viruses [12,13].…”

Section: Introductionmentioning

confidence: 99%

Antiviral bioactivity of renewable polysaccharides against Varicella Zoster

2019

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Although several effective treatments exist against Varicella zoster virus (VZV), resistant strains have emerged and the treatment is usually not definite and may have various undesired side effects. Thus, alternative treatment options are necessary. Here we studied the inhibitory effects of natural polysaccharides (PSs) obtained from renewable sources, varied by their structure and charge, on VZV infection in vitro, using a plaque assay. In terms of selectivity indices, almost all the tested PSs were very active; in the order of λ > ἰ > G > κ > P against VZV compared to Acyclovir as a reference drug and exhibited dose-dependent behavior. Our results, which showed a strong inhibition of VZV infection when the cells were treated with ἰ only at the time of infection or only post infection may indicate a multistep inhibitory effect. It seems that ἰ may block different stages of the virus replication cycle including early steps such as absorption and penetration to the host cells and also late steps after the penetration into the host cells. These results are part of an ongoing research that highlights the PSs as potential novel nontoxic candidates that can be used against VZV, and contributes to the elucidation of their mode of action.

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Section: Introductionmentioning

confidence: 99%

Antiviral bioactivity of renewable polysaccharides against Varicella Zoster

2019

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“…The latent virus is reactivated spontaneously causing recurrent infections in infected patients [6]. Although it can effectively be treated with nucleoside analogs such as acyclovir (ACV), but still the search for new effective antiherpetic drugs is important due to the development of ACV-resistant herpes viruses mutants particularly in immunosuppressed and in immunode iciency syndrome patients [7][8][9][10][11][12][13][14][15]. In addition, ACV and other available nucleoside analogs have different undesired side effects (like nausea, vomiting, headache and others) [16] and are not highly effective against reactivated herpes viruses [17,18].…”

Section: Introductionmentioning

confidence: 99%

Antiviral activity of Eucalyptus camaldulensis leaves ethanolic extract on herpes viruses infection

Huleihel¹

2017

Int J Clin Virol

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Eucalyptus camaldulensis (Ec) is considered as a traditional medicinal plant with valuable therapeutic effects. Here we evaluated the antiviral activity of its ethanolic leave extract on different herpes viruses. Vero cells were infected with either of the tested viruses [herpes simplex virus-1 and 2 (HSV-1, HSV-2) and Varicella-Zoster Virus (VZV)] with or without treatment with Ec extract and viral infection development was evaluated by plaque assay. Our results showed signifi cant antiviral activity of the examined extract against all tested viruses. The 80%-MeOH fraction of this extract offered the highest activity against these viruses with 50% inhibitory concentration (IC 50) of 0.1±0.08, 0.3±0.02 and 1±0.03 μg/ml against HSV-1, HSV-2 and VZV respectively and 50% cytotoxicity (CC 50) at 700 μg/ml. The highest antiviral effect of this fraction was obtained mainly when it was added during and post infection (p.i.) or when it was added only p.i. Also, this fraction signifi cantly reduced the amount of infective endogenous viral particles in cells that were treated with the 80%-MeOH fraction only post viral entry into the host cells. A synergistic antiviral effect against all tested viruses was also observed when cells were treated with a combination of acyclovir (ACV) and 80%-MeOH fraction of Ec. Further study is required for the isolation and identifi cation of the anti-virally active component/s of this fraction.

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Design, Synthesis and Antiviral Activity Studies of Schizonepetin Derivatives

Cited by 2 publications

References 17 publications

Antiviral bioactivity of renewable polysaccharides against Varicella Zoster

Antiviral bioactivity of renewable polysaccharides against Varicella Zoster

Antiviral activity of Eucalyptus camaldulensis leaves ethanolic extract on herpes viruses infection

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