Design, Synthesis and Application of Multifunctional Chiral Aminophosphine Catalyst for Asymmetric Intermolecular Cross Rauhut‐Currier Reaction

Abstract

Comprehensive Summary A series of structurally novel multifunctional chiral aminophosphine catalysts were developed through a concise synthetic strategy from easily available starting materials. The highly enantioselective intermolecular cross Rauhut‐Currier reactions of vinyl ketones with 3‐acyl acrylates and 2‐ene‐1,4‐diones catalyzed by (S,S)‐5a were well realized, generating a wide range of the structurally important chiral multicarbonyl products in good to excellent yields with high stereocontrol (up to 97% yield, 99% ee). In addition, a series of 31P NMR experiments were carried out to further investigate the catalytic process.