Design, Synthesis and Biological Activity of Ethyl 2-(N-Substituted-arylsulfonamido)-2-oxoacetate

Discovery, Synthesis and Evaluation of a Ketol‐Acid Reductoisomerase Inhibitor

“…This problem was also reported by Wang et al who synthesized a series of sulfonamide derivatives of IpOHA. [25] The electron withdrawing sulfone likely makes the ketone more susceptible to nucleophilic attack by the hydroxide anion.…”