Design, Synthesis and Biological Assessment of Thiazole Derivatives as Possible Antioxidant and Antimicrobial Agents

Isha, .; Sachan, Neetu

doi:10.9734/jpri/2021/v33i53a33635

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…Heterocycles containing nitrogen and sulphur are an essential class of therapeutic molecules. Thiazole (1) is a heterocyclic structure with an aromatic five-membered ring that contains both nitrogen and a sulphur atom (4)(5).…”

Section: Introductionmentioning

confidence: 99%

Thiazole Scaffold: An Overview on Its Synthetic and Pharmaceutical Aspects

Mishra¹,

Sachan²

2022

ECS Trans.

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Thiazole and its derivatives have risen to prominence as an important scaffold, attracting the attention of researchers in the area of medicinal chemistry due to their remarkable variety of biological activities. The thiazole moiety has been identified as an essential component in the structure of therapeutic agents including Ravuconazole, Sulfathiazole, Meloxicam, and Ritonavir, and is extensively utilized as an antimicrobial, anticancer, anti-inflammatory, antioxidant, and antiretroviral agent. The thiazole moiety's versatility has already been shown by the vast use of its derivatives with anticancer, anti-HIV, antibacterial, anti-inflammatory, antiallergic, antioxidant, and analgesic actions. For its unique potential in various activities, this moiety's broad array of living response accounts has captivated numerous researchers. This study aims to further the biological potential of thiazole derivatives, whether as a core moiety or as a substituent, to eventually synthesize a diverse array of therapeutic entities.

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Section: Introductionmentioning

confidence: 99%

Thiazole Scaffold: An Overview on Its Synthetic and Pharmaceutical Aspects

Mishra¹,

Sachan²

2022

ECS Trans.

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Structural characterization, DFT calculations, ADMET studies, antibiotic potentiating activity, evaluation of efflux pump inhibition and molecular docking of heterocylcic chalcone (E)-1-(4-aminophenyl)-3-(thiophen-2-yl)prop-2-en-1-one

da Silva,

da Silva Mendes,

Almeida-Neto

et al. 2024

Journal of Molecular Structure

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Bioactive Exploration in Functional Foods: Unlocking Nature's Treasures

Mittal,

Mishra,

Sharma

et al. 2024

CPB

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Background:: Functional foods offer an appealing way to improve health and prevent chronic diseases, and this subject has received much attention lately. They are effective in preventing chronic diseases like cancer, diabetes, heart disease, and obesity, according to research. Objective:: This work presents an in-depth analysis of functional foods, covering key challenges from a scientific, legal, and commercial perspective. Methods:: Multiple databases were searched to find studies on functional foods included in the systematic literature review. Various aspects of functional foods, from their classification, impact on human wellness, effectiveness in inhibiting chronic diseases, the regulatory environment, global market trends, and industry challenges, are all clarified in this thorough review. Results:: This study aims to enhance understanding and establish a pathway for functional foods to be acknowledged as valid choices in the field of dietary supplements. It provides a thorough investigation of bioactive compounds present in functional foods, including but not limited to polyphenols, carotenoids, omega fatty acids, prebiotics, probiotics, and dietary fiber, along with an overview of their potential to mitigate chronic illnesses. We engage in an in-depth exploration of regulatory frameworks, shed light on groundbreaking research advancements, and meticulously examine strategies for commercialization and the variety of global challenges that accompany them. Establishing scientific consensus, navigating complex regulatory processes, dealing with skeptical consumers, and rising levels of competition are all problems that need to be solved in this field. Conclusion:: The field of functional foods can advance further, promoting better public health outcomes, by deeply comprehending and addressing these complex dimensions.

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Design, Synthesis and Biological Assessment of Thiazole Derivatives as Possible Antioxidant and Antimicrobial Agents

Cited by 5 publications

References 21 publications

Thiazole Scaffold: An Overview on Its Synthetic and Pharmaceutical Aspects

Thiazole Scaffold: An Overview on Its Synthetic and Pharmaceutical Aspects

Structural characterization, DFT calculations, ADMET studies, antibiotic potentiating activity, evaluation of efflux pump inhibition and molecular docking of heterocylcic chalcone (E)-1-(4-aminophenyl)-3-(thiophen-2-yl)prop-2-en-1-one

Bioactive Exploration in Functional Foods: Unlocking Nature's Treasures

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