2017
DOI: 10.1016/j.bmcl.2017.09.055
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Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer’s disease

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Cited by 30 publications
(20 citation statements)
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“…Sang et al designed and synthesized phthalimide‐alkylamine derivatives ( 193a ‐ m ) and investigated them for hMAO‐B inhibitory activity (Figure ). The results indicated that the compounds were significantly selective hMAO‐BIs and displayed moderate to good MAO‐B inhibition (IC 50 = 2.6‐13.1 μM).…”
Section: Discovery and Development Of Mao‐b Inhibitors (2015‐2018)mentioning
confidence: 99%
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“…Sang et al designed and synthesized phthalimide‐alkylamine derivatives ( 193a ‐ m ) and investigated them for hMAO‐B inhibitory activity (Figure ). The results indicated that the compounds were significantly selective hMAO‐BIs and displayed moderate to good MAO‐B inhibition (IC 50 = 2.6‐13.1 μM).…”
Section: Discovery and Development Of Mao‐b Inhibitors (2015‐2018)mentioning
confidence: 99%
“…Phthalimide‐alkylamine derivatives ( 193a ‐ m ) . hMAO, human monoamine oxidase; IC 50 , half maximal inhibitory concentration…”
Section: Discovery and Development Of Mao‐b Inhibitors (2015‐2018)mentioning
confidence: 99%
See 1 more Smart Citation
“…The phthalimide is a bicyclic heterocyclic scaffold and its derivatives have diverse range of biologically activities such as anti‐inflammatory, anticonvulsant, hypolipidemic, analgesic, and immunomodulatory activities . Recently, several derivatives of phthalimide with high inhibitory activity against AChE have been reported ( Figure A and B ) . On the other hand, two dithiocarbamate derivatives C and D exhibited good inhibitory activity against cholinesterases ( Figure ) .…”
Section: Introductionmentioning
confidence: 99%
“…[8 -13] Recently, several derivatives of phthalimide with high inhibitory activity against AChE have been reported ( Figure 1A and B). [14,15] On the other hand, two dithiocarbamate derivatives C and D exhibited good inhibitory activity against cholinesterases ( Figure 1). [16,17] Keeping in view of the above mentioned importance of phthalimide and dithiocarbamate pharmacophores, herein, we designed, synthesized, and evaluated a novel series of phthalimidedithiocarbamate hybrids as new anti-cholinesterase agents (Figure 1, compounds 7a-7i and 7j -7o).…”
Section: Introductionmentioning
confidence: 99%