2024
DOI: 10.1021/acs.jafc.3c08138
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Design, Synthesis, and Biological Evaluation of Novel Purine Derivatives as Herbicide Safeners

Jie Peng,
Shuang Gao,
Jing-Hu Bi
et al.

Abstract: Mesosulfuron-methyl, an inhibitor of acetolactate synthase (ALS), has been extensively used in wheats. However, it can damage wheat (Triticum aestivum) and even lead to crop death. Herbicide safeners selectively shield crops from such damage without compromising weed control. To mitigate the phytotoxicity of mesosulfuron-methyl in crops, several purine derivatives were developed based on active substructure splicing. The synthesized title compounds underwent thorough characterization using infrared spectroscop… Show more

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