Design, synthesis and biological evaluation of novel 1,2,4-triazolo and 1,2,4-triazino[4,3-a]quinoxalines as potential anticancer and antimicrobial agents

Abstract

Compound 9a showed dual anticancer and antimicrobial activity and compound 16 showed a broad spectrum antimicrobial activity.

Solvent‐Free One‐Pot Tandem Multicomponent Synthesis of Triazolothiadiazinyl Coumarins and Their Antimicrobial Properties

“…Further anti microbial activity evaluation was carried out to determine the minimum inhibitory concentration [MIC], minimum bactericidal concentrations [MBC] and fungicidal concentration by using standard MIC and MBC protocol,, the MIC and MBC values were determined in μg/mL and reported in Table , , & 6 . The MIC and MBC experimental studies reveal that the compounds 4 g, 6e and 6 g were shown potent antimicrobial activity against both Gram positive and Gram negative bacterial strains.…”

Electrosynthesis of C3 Alkoxylated Quinoxalin‐2(1H)‐ones through Dehydrogenative C–H/O–H Cross‐Coupling

“…Meanwhile, quinoxalin‐2(1 H )‐ones have attracted much attention due to their abundant existence in anti‐inflammatory, antineoplastic, antithrombotic agents and aldose reductase inhibitors Conventional installation of C–O bond at C3 of quinoxalin‐2(1 H )‐ones largely rely on the nucleophilic substitution between 3‐chloroquinoxalin‐2(1 H )‐ones and phenols (see Scheme a) . Tremendous efforts have been made to develop C–H/O–H direct coupling to avoid the use of pre‐functionalized substrates and strong basic conditions during the synthesis of 3‐alkoxylated quinoxalin‐2(1 H )‐ones.…”

Cu–N‐heterocyclic carbene‐catalysed synthesis of 2‐aryl‐3‐(arylethynyl)quinoxalines from one‐pot tandem coupling ofo‐phenylenediamines and terminal alkynes

“…Quinoxaline thiosemicarbazone ligands were explored with copper and zinc complexes in diabetes‐induced Wister rats and those compounds showed prominent reduction in blood glucose level, exhibited good activity in oral glucose tolerance test and showed low toxicity . These derivatives also exhibit other biological activities such as anticancer,7a antibacterial,7b anti‐inflammatory7c and antimicrobial7d activities. Furthermore, the quinoxaline ring is a core structure of several drug molecules and acceptors such as clofazimine, echinomycin and actinomycin 8a,b,c.…”