Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-based derivatives as multitarget anti-Alzheimer agents
Mohammed Salah Ayoup,
Mohamed Reda Barakat,
Hamida Abdel-Hamid
et al.
Abstract:A series of novel 1,2,4-oxadiazole-based derivatives were synthesized and evaluated for their potential anti-Alzheimer disease activity. The results revealed that compounds 2b, 2c, 2d, 3a, 4a, 6, 9a, 9b, and...
A metal-free, iodine-catalyzed protocol for the synthesis of biologically significant 5-aroyl 1,2,4-oxadiazole scaffolds has been developed using aryl methyl ketones and amidoximes.
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