Design, synthesis and biological evaluation of novel dual-targeting fluorescent probes for detection of Fe3+ in the lysosomes of hepatocytes mediated by galactose-morpholine moieties

Recent advances in small-molecule fluorescent probes with the function of targeting cancer receptors

“…Then, Wang et al improved the targeting groups of lysosomes and synthesized probes 27a , 27b and 27c . 82 The probes used classical morpholine groups instead of imidazole to target lysosomes (Fig. 28b), which fused well with Lyso-Tracker Red in HepG2 cells, with Pearson's coefficients of 0.830, 0.841, and 0.866, respectively.…”

Polymerization-induced emission (PIE) of multifunctional polyamides synthesized by Ugi polymerization and targeted imaging of lysosomes

“…15 Therefore, the development of sensitive and reliable Fe 3+ detection probes in natural and human environments is of great significance in dealing with environmental pollution and preventing related diseases. 16,17…”

“…15 Therefore, the development of sensitive and reliable Fe 3+ detection probes in natural and human environments is of great significance in dealing with environmental pollution and preventing related diseases. 16,17 As one of the important organelles, lysosomes consist of a large number of acidic vesicles (pH 4-5), and play an irreplaceable role in maintaining the stability of the intracellular environment, and also mediate physiological processes such as protein degradation, recovery of damaged organelles, macromolecular digestion, plasma membrane repair and autophagy. 18,19 In addition to this, lysosomes are involved in a variety of pathological lesions, including inflammation, tumor formation, and several neurodegenerative diseases.…”

Aggregation‐induced emission‐active poly (β‐lactam) prepared by Staudinger polymerization as specific probe to Fe3+ ions and its antimicrobial properties

“…In the natural environment, when the wastewater containing iron is discharged into the water system, the water quality is not only deteriorated, but also the generated Fe(OH) 3 colloid adsorbs other pollutants under alkaline conditions, which is difficult to remove 22 . In the organisms, Fe 3+ ion is an essential trace element for the growth and development of animals and plants, and acts an important role in myoglobin synthesis and other life activities 23 . However, the insufficient or excessive Fe 3+ intake may leads to biological disorders.…”

“…22 In the organisms, Fe 3+ ion is an essential trace element for the growth and development of animals and plants, and acts an important role in myoglobin synthesis and other life activities. 23 However, the insufficient or excessive Fe 3+ intake may leads to biological disorders. Therefore, the development of detection of iron ions including sensitive and reliable Fe 3+ probe is of great significance for the prevention of environmental pollution and occurrence of disease.…”