Design, synthesis and biological evaluation of multitarget hybrid molecules containing NHC-Au(I) complexes and carbazole moieties

D’Amato, A.; Iacopetta, D.; Ceramella, J.; Troiano, R.; Mariconda, A.; Catalano, A.; Marra, M.; Saturnino, C.; Rosano, C.; Sinicropi, M.S.; Longo, P.

doi:10.1016/j.ejmech.2024.116757

European Journal of Medicinal Chemistry

2024

DOI: 10.1016/j.ejmech.2024.116757

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Design, synthesis and biological evaluation of multitarget hybrid molecules containing NHC-Au(I) complexes and carbazole moieties

A. D’Amato,

D. Iacopetta,

J. Ceramella

et al.

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Cited by 2 publications

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An updated overview on nitrogen-rich azole-based gold coordination complexes as potent anticancer agents

Ghorbanpour,

Soltani

2025

Coordination Chemistry Reviews

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An updated overview on nitrogen-rich azole-based gold coordination complexes as potent anticancer agents

Ghorbanpour,

Soltani

2025

Coordination Chemistry Reviews

View full text Add to dashboard Cite

Silver N-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents

Ceramella,

Catalano,

Mariconda

et al. 2024

Pharmaceuticals

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The strict connections/interactions between microbial infections and cancer are nowadays widely accepted. Hence, the dual (or multiple) targeting of microbial infections and cancer is an essential issue to be addressed. In this context, metal complexes have gained considerable importance and effectiveness in medicinal chemistry. Particularly, N-heterocyclic carbene (NHC) complexes with transition metals have emerged as very promising compounds. Among the myriad of NHC–metal complexes, those bearing silver will be the subject of this review. Numerous Ag(I)-NHC complexes have revealed high antibacterial and/or anticancer properties, even higher than those of reference drugs. Herein, we summarize the most recent studies while also discussing the proposed mechanism of action and offering an interesting remark about the research in this field. Literature databases (PubMed/MEDLINE, Scopus, and Google Scholar) were used as sources to search the literature, referring to the last five years.

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Design, synthesis and biological evaluation of multitarget hybrid molecules containing NHC-Au(I) complexes and carbazole moieties

Cited by 2 publications

References 58 publications

An updated overview on nitrogen-rich azole-based gold coordination complexes as potent anticancer agents

An updated overview on nitrogen-rich azole-based gold coordination complexes as potent anticancer agents

Silver N-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents

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