Design, Synthesis and Biological Evaluation of Schiff Bases and Their Co(II), Cu(II), Ni(II) Chelates  from Derivative Containing Indole Moiety Bearing-Triazole

Al-Shemary, Rehab K.

doi:10.17628/ecb.2017.6.433-439

Cited by 7 publications

(1 citation statement)

References 13 publications

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“…The derivatives of 1,2,4triazole have anticancer [11], antimicrobial [12], antidepressant [13] and antioxidant [14] activities. Among medicinal drugs, triazole-based anticancer, antifungal, antiviral, and antibacterial drugs are available on the market [15]. Coordination complexes formed by the joining of central metal atoms or ion containing empty orbitals with neutral and ionic atoms carrying electron lone pairs (ligand).…”

Section: Introductionmentioning

confidence: 99%

Metal(II) triazole complexes: Synthesis, biological evaluation, and analytical characterization using machine learning-based validation

et al. 2023

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The synthesis of many transition metal complexes containing 3,5-diamino-1,2,4-triazole (Hdatrz) as a ligand with different counter anions Br⎺, Cl⎺, ClO4⎺ and SO42- has been studied extensively, but the chemistry of transition metal nitrate and acetate compounds and their reactivity are relatively unexplored. In this research work, two new series of metal(II) complexes (M = Ni, Co, and Zn) {[Ni3(Hdatrz)6(H2O)6](NO3)6 (1), [Co3(Hdatrz)6(H2O)6](NO3)6 (2), [Zn3(Hdatrz)6(H2O)6](NO3)6 (3), [Ni3(Hdatrz)6(H2O)6](OAc)6 (4), [Co3(Hdatrz)6(H2O)6] (OAc)6 (5) and [Zn3(Hdatrz)6(H2O)6](OAc)6 (6)} have been synthesized. These synthesized complexes were characterized by various physicochemical techniques such as UV-vis spectroscopy, Fourier transform infrared spectroscopy, and magnetic susceptibility measurements. All six complexes were found to be trinuclear and bridged through the Hdatrz ligand. Spectral data suggested a distorted octahedral environment around the central metal ions in these complexes. It also revealed that the NH and OH groups are involved in hydrogen bonding. These complexes were tested against the fungal strains Colletotrichum gloeosporioides and Aspergillus niger. These synthesized complexes have not been observed to have antifungal activities. The machine learning K-nearest neighbours evaluates the analytical characteristics and solubility behavior of the metal complexes. Machine learning models provide results with 75% precision.

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Section: Introductionmentioning

confidence: 99%

Metal(II) triazole complexes: Synthesis, biological evaluation, and analytical characterization using machine learning-based validation

et al. 2023

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Schiff Bases: A Versatile Fluorescence Probe in Sensing Cations

et al. 2023

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Exploring the Enzyme Inhibition Potential of Schiff Base and Metal Complexes of Benzothiophene Derivatives

Dhanya,

Rajimon,

Mohanan

et al. 2024

Discov. Chem.

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Benzothiophene, a sulfur-containing heterocycle, plays a crucial role in pharmaceutical and biological research due to its low toxicity, high solubility, and bioavailability. This aromatic structure, comprising a six-membered ring fused with a thiophene moiety, serves as a key scaffold for synthesizing biologically significant compounds. Benzothiophene derivatives exhibit diverse biological and pharmacological activities, including antimicrobial, anticancer, anti-inflammatory, antioxidant, antimalarial, antidiabetic, and enzyme-inhibiting properties. This study utilizes the synthesis of Schiff base ligands with the benzothiophene moiety to build coordination complexes with metals. The electron-rich sulfur and aromaticity of the benzo[b]thiophene core are well-known for their ability to stabilise the metal centres and have an impact on the coordination compounds' overall shape and reactivity. This review focuses on the advancements in the biological activities of benzothiophene compounds, emphasizing their potential as Schiff base metal complexes with enzyme-inhibiting capabilities. The discussion aims to provide new insights into the development of safer and more effective benzothiophene-based medicinal drugs, analytical agents, and pathological probes.

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Design, Synthesis and Biological Evaluation of Schiff Bases and Their Co(II), Cu(II), Ni(II) Chelates from Derivative Containing Indole Moiety Bearing-Triazole

Cited by 7 publications

References 13 publications

Metal(II) triazole complexes: Synthesis, biological evaluation, and analytical characterization using machine learning-based validation

Metal(II) triazole complexes: Synthesis, biological evaluation, and analytical characterization using machine learning-based validation

Schiff Bases: A Versatile Fluorescence Probe in Sensing Cations

Exploring the Enzyme Inhibition Potential of Schiff Base and Metal Complexes of Benzothiophene Derivatives

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