Design, synthesis, and biological evaluation of 2, 4-dichlorophenoxyacetamide chalcone hybrids as potential c-Met kinase inhibitors

Bhojwani, Heena R.; Patil, None Sanskruti; Joshi, Urmila J.; Bhor, Vikrant M.; Bedi, Parul

doi:10.1007/s00044-022-02986-9

Cited by 2 publications

(5 citation statements)

References 67 publications

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“…, 35); 197 (7); 183 (100); 135 (36); 106 (33); 92 (33); 65 (12); 32 (4). (20); 133 (13); 105 (13); 91 (15); 41 (4.5); 32 (10).…”

Section: -(4-chloro-2-isopropyl-5-methylphenoxy)-n-phenylacetamide (3bunclassified

“…Phenols can be utilized to synthesize N -phenyl-2-phenoxyacetamide compounds, as shown in Figure . These compounds have garnered attention from researchers due to their diverse range of biological activities, including anti-inflammatory effects, anticancer properties, , analgesic effects, antimicrobial properties, and potential against SARS-CoV-2 …”

Section: Introductionmentioning

confidence: 99%

“…For instance, thymol (2-isopropyl-5-methylphenol) is a crystalline and colorless phenolic monoterpene that can be found in essential oils derived from several plants, including thyme (Thymus vulgaris), oregano (Origanum vulgare), 6 and rosemary pepper (Lippia sidoides). 7 This substance has demonstrated antimicrobial, 8 antifungal, 9 antioxidant, 10 and phytotoxic activities. 11,12 Despite its broad biological activity, thymol has a potent scent and is highly volatile.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Phenols can be utilized to synthesize N-phenyl-2-phenoxyacetamide compounds, as shown in Figure 1. These compounds have garnered attention from researchers due to their diverse range of biological activities, including antiinflammatory effects, 13 anticancer properties, 14,10 analgesic effects, 8 antimicrobial properties, 9 and potential against SARS-CoV-2. 15 The herbicidal potential of N-phenyl-2-phenoxyacetamides was reported in the study by Wu et al, 16 demonstrating that these compounds may have significant phytotoxic potential.…”

Section: ■ Introductionmentioning

confidence: 99%

“…This substance has demonstrated antimicrobial, antifungal, antioxidant, and phytotoxic activities. , Despite its broad biological activity, thymol has a potent scent and is highly volatile. Therefore, incorporating other functional groups and increasing the molecular weight make it feasible to overcome these drawbacks.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Phytocytogenotoxic Activity of N-Phenyl-2-phenoxyacetamides Derived from Thymol

Pinheiro,

da Costa,

Corrêa

et al. 2024

J. Agric. Food Chem.

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The excessive use of herbicides has caused a series of problems related to human health, environmental pollution, and an increase in the resistance of plants to commercial herbicides. As an alternative, natural compounds and their semisynthetic derivatives have been widely studied to obtain environmentally friendly and more effective herbicides than the usual ones. In view of these factors, the aim of this work was to synthesize new molecules with herbicidal potential using thymol as a starting material, a natural phenol that has a pronounced phytotoxic effect. Novel N-phenyl-2-thymoxyacetamides were synthesized and characterized by MS and by 1 H and 13 C NMR. All prepared molecules were subjected to phytotoxic and cytotoxic activity assays using Lactuca sativa L. and Sorghum bicolor L. as model plants. Molecules containing chlorine in the para position of the thymoxy group exhibited phytotoxic and cytogenotoxic effects superior to those of the commercial herbicides 2,4-D and glyphosate.

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“…, 35); 197 (7); 183 (100); 135 (36); 106 (33); 92 (33); 65 (12); 32 (4). (20); 133 (13); 105 (13); 91 (15); 41 (4.5); 32 (10).…”

Section: -(4-chloro-2-isopropyl-5-methylphenoxy)-n-phenylacetamide (3bunclassified

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and Phytocytogenotoxic Activity of N-Phenyl-2-phenoxyacetamides Derived from Thymol

Pinheiro,

da Costa,

Corrêa

et al. 2024

J. Agric. Food Chem.

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Design, synthesis and biological evaluation of 4-(4-aminophenoxy)picolinamide derivatives as potential antitumor agents

Dai,

Zhang,

et al. 2023

European Journal of Medicinal Chemistry

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Design, synthesis, and biological evaluation of 2, 4-dichlorophenoxyacetamide chalcone hybrids as potential c-Met kinase inhibitors

Cited by 2 publications

References 67 publications

Synthesis and Phytocytogenotoxic Activity of N-Phenyl-2-phenoxyacetamides Derived from Thymol

Synthesis and Phytocytogenotoxic Activity of N-Phenyl-2-phenoxyacetamides Derived from Thymol

Design, synthesis and biological evaluation of 4-(4-aminophenoxy)picolinamide derivatives as potential antitumor agents

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