Design, synthesis, and biological evaluation of novel thieno[3,2-<i>d</i>]pyrimidine derivatives as potent antitumor agents

Zhang, Yadong; Shen, Jiwei; Li, JiaWei; Wang, Zhi; Wang, Yue; Zhu, Yan; Ding, Shi; Zhou, YunPeng; Chen, Ye; Liu, Ju

doi:10.1039/d3nj03576j

New J. Chem.

2023

DOI: 10.1039/d3nj03576j

|View full text |Cite

Design, synthesis, and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives as potent antitumor agents

Yadong Zhang,

Jiwei Shen,

JiaWei Li

et al.

Abstract: Two series of substituted thieno[3,2-d]pyrimidine derivatives as EZH2 inhibitors were synthesized via structural modifications of tazemetostat.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 33 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

One‐Pot Three‐Component Construction of 2,4‐Diarylbenzo[4,5] thieno[3,2‐d] pyrimidines Using Elemental Sulfur as a Sulfur Source

Li,

Wen,

2024

ChemistrySelect

View full text Add to dashboard Cite

An efficient method for the construction of 2,4‐diarylbenzo[4,5]thieno[3,2‐d]pyrimidines through the base‐promoted one‐pot three‐component tandem reactions of o‐nitrochalcones, benzamidine hydrochlorides, and elemental sulfur is described. The salient features of this protocol are the use of cheap and abundant sulfur source, readily available starting materials, transition‐metal‐free and mild conditions, satisfactory yield, and simple workup procedures. This transformation can also carry out on gram scale.

show abstract

One‐Pot Three‐Component Construction of 2,4‐Diarylbenzo[4,5] thieno[3,2‐d] pyrimidines Using Elemental Sulfur as a Sulfur Source

Li,

Wen,

2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

Amorphous-nanocrystalline dual-phase structured Fe78Si13B9 alloy ribbons and their efficiency for degradation of direct yellow dye

Zhao,

Chen,

et al. 2024

Reac Kinet Mech Cat

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Design, synthesis, and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives as potent antitumor agents

Abstract: Two series of substituted thieno[3,2-d]pyrimidine derivatives as EZH2 inhibitors were synthesized via structural modifications of tazemetostat.

Cited by 2 publications

References 33 publications

One‐Pot Three‐Component Construction of 2,4‐Diarylbenzo[4,5] thieno[3,2‐d] pyrimidines Using Elemental Sulfur as a Sulfur Source

One‐Pot Three‐Component Construction of 2,4‐Diarylbenzo[4,5] thieno[3,2‐d] pyrimidines Using Elemental Sulfur as a Sulfur Source

Amorphous-nanocrystalline dual-phase structured Fe78Si13B9 alloy ribbons and their efficiency for degradation of direct yellow dye

Contact Info

Product

Resources

About