Design, Synthesis and Biological Evaluation of Some Schiff Base Ligand as Antimalarial Agents.

Garg, Gopal; Acharya, Ashish; Patel, Kuldeep

doi:10.7439/ijbr.v4i3.241

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Compounds 1-12 showed very low antimalarial activity, with %parasite viability ranges from 62.6 -117.6%. Generally test compounds that reduces parasite viability to < 10-20% implies relatively high antimalarial activity [43]. This might be attributed to the lipophilicity nature of the Schiff bases which restricted permeation into the P. falciparum strain cell wall [44].…”

Section: Resultsmentioning

confidence: 99%

Antimalarial, Anti-trypanosomiasis, Anti-HIV and Cytotoxicity Studies of Some Ferrocenyl Schiff bases

2017

Nov. 27-28, 2017 South Africa ASETWM-17, RCABES-17 &Amp; EBHSSS-17

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Abstract-An investigation into the potential biological application of a series of Ferrocenyl Schiff bases (compounds 5-12) was carried out by evaluating their antimalarial, antitrypanosomiasis, antiHIV activities and toxicity towards HeLa cells. The synthesized ferrocenyl Schiff bases (5-12) were found to exhibit higher biological activities investigated in this study than their precursors (Compounds 1-4). Among the derivatives compound 5 and 7 showed appreciable anti-trypanosomiasis activity. The anti-HIV activity showed that these compounds 5-12 have significant anti-HIV activity up to about 66% enzyme inhibition in the case of compound 7. All the compounds showed low cytotoxicity towards HeLa cells.

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Section: Resultsmentioning

confidence: 99%

Antimalarial, Anti-trypanosomiasis, Anti-HIV and Cytotoxicity Studies of Some Ferrocenyl Schiff bases

2017

Nov. 27-28, 2017 South Africa ASETWM-17, RCABES-17 &Amp; EBHSSS-17

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“…Schiff base metal complexes, which are derived from halogenated salicylaldehyde, have a broad variety of applications in research involving biocatalytic, anti-HIV, antibacterial, and luminous probes for DNA and RNA breakage reactions [23][24][25]. These derivatized complexes are also employed as fungicides, insecticides, and flavoring agents for bouquets and liquor [26][27][28][29][30][31][32].…”

Section: Introduction To Metal Complexesmentioning

confidence: 99%

Metal Complex

Laxman Sangle,

Barku More,

V. Thakare

2024

Novelties in Schiff Bases

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The scientific community has given Schiff-based metallic complexes much attention because of their distinctive properties and numerous uses in a variety of fields, including biology and industry. The nature of the ligands and metal ions influences coordination chemistry. The biological activities of these complexes include cytostatic, antiviral, antibacterial, anticancer, and antifungal effects. They also have remarkable catalytic activity. With its diverse uses, coordination complexes serve a vital role in research.

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DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands

Zeng

et al. 2015

Transition Met Chem

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Design, Synthesis and Biological Evaluation of Some Schiff Base Ligand as Antimalarial Agents.

Cited by 5 publications

References 13 publications

Antimalarial, Anti-trypanosomiasis, Anti-HIV and Cytotoxicity Studies of Some Ferrocenyl Schiff bases

Antimalarial, Anti-trypanosomiasis, Anti-HIV and Cytotoxicity Studies of Some Ferrocenyl Schiff bases

Metal Complex

DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands

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