Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors

Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases

“…All of the quinolin-2(1H)-one-derived Schiff base ligands (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) were synthesised by an equimolar condensation reaction between substituted aromatic aldehydes and 7-amino-4-methylquinolin-2(1H)-one (1) in hot ethanol. A stirred suspension of 1 (2 mmol, 0.348 g) and the appropriate aromatic aldehyde (2 mmol) in hot ethanol (40 mL) was refluxed for 4 h. On cooling to room temperature, coloured precipitates (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) formed in good yields (>70%), were filtered off and dried in a vacuum oven for two weeks.…”

“…A stirred suspension of 1 (2 mmol, 0.348 g) and the appropriate aromatic aldehyde (2 mmol) in hot ethanol (40 mL) was refluxed for 4 h. On cooling to room temperature, coloured precipitates (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) formed in good yields (>70%), were filtered off and dried in a vacuum oven for two weeks. The general structure of the ligands with the numbering system used in this work is shown in Fig.…”

“…General structure of a quinolin-2(1H)-one derived Schiff base with numbering system used in this report. Table 1 Ligand names, their relative substituents and positions of R groups for compounds (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

“…They are also used as antibacterial, antifungal, anti-inflammatory, antitubercular, anticancer, antineoplastic, anti-ischemic, anti-allergic, antihypertensive and antiulcerative agents [5][6][7][8][9]. Recently, a novel series of quinolinones have shown potent inhibitory activity against human immunodeficiency virus type-1 (HIV-1) virus and also exhibited promising activity against several non-nucleoside reverse transcriptase inhibitors (NNRTIs) [10]. One of the 6-functionalised quinolinone derivatives was also reported to possess potent antitumor activity and is undergoing human phase II/III clinical trails as an orally active antitumor drug for the treatment of haematological and solid tumours in the nanomolar range [8].…”

One-pot diastereoselective synthesis of new spiro indenoquinoxaline derivatives containing cyclopropane ring

“…3 Due to diversity of cyclopropane containing compounds with biological activity, chemists have tried to find novel and facile methods for synthesis of these compounds. 4,5 Indenoquinoxaline derivatives are important classes of nitrogen containing heterocycles and they have applications in dyes and are useful intermediates in organic synthesis and have also been used as building blocks for the synthesis of organic semiconductors.…”