Design, Synthesis, and Characterization of Self-assembled Peptide Nanostructures toward Peptide-directed Biomineralization

Tomizaki, Kin‐ya; Kotera, Tatsuki; Naito, Hideki; Wakizaka, Shota; Yamamoto, Shinichi

doi:10.1246/cl.2011.699

Cited by 8 publications

(3 citation statements)

References 14 publications

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“…We previously designed and synthesized a series of amphiphilic β-sheet-forming nonapeptides and showed that they self-assemble to form nanofibers at relatively low peptide concentrations of ∼100 μM in water. The use of water avoids potential metal/salt contamination by buffer solutions. − Our results demonstrated that short peptides hold potential for practical applications and encouraged us to employ them as templates to align ZnO nanocrystals along self-assembled peptide nanostructures. Peptides provide significant advantages in structural diversity and manipulation of template molecules compared to small (e.g., amino acids) and large (e.g., proteins) biomolecules.…”

Section: Introductionmentioning

confidence: 87%

Biomimetic Alignment of Zinc Oxide Nanoparticles along a Peptide Nanofiber

et al. 2012

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Zinc oxide (ZnO) has potential applications in solar cells, chemical sensors, and piezoelectronic and optoelectronic devices due to its attractive physical and chemical properties. Recently, a solution-phase method has been used to synthesize ZnO crystals with diverse (from simple to hierarchical) nanostructures that is simple, of low cost, and scalable. This method requires template molecules to control the morphology of the ZnO crystals. In this paper, we describe the design and synthesis of two short peptides (RU-003,Ac-AIEKAXEIA-NH(2); RU-027, EAHVMHKVAPRPGGGAIEKAXEIA-NH(2); X = l-2-naphthylalanine) and the characterization of their self-assembled nanostructures. We also report their potential for ZnO mineralization and the alignment of ZnO nanoparticles along peptide nanostructures at room temperature. Interestingly, nonapeptide RU-003 predominantly formed a straight fibrous structure and induced the nucleation of ZnO at its surface, leading to an alignment of ZnO nanoparticles along a peptide nanofiber. This novel method holds promise for the room-temperature fabrication of ZnO catalysts with increased specific surface area, ZnO-gated transistors, and ZnO-based nanomaterials for optical applications.

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Section: Introductionmentioning

confidence: 87%

Biomimetic Alignment of Zinc Oxide Nanoparticles along a Peptide Nanofiber

et al. 2012

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“…Therefore, SAPs are highly versatile structural and functional molecules. To date, many designed SAPs have been reported, [5][6][7][8][9][10][11] and most of these SAPs are roughly divided into three classes: b-sheet peptides, a-helix peptides and peptide amphiphiles.…”

Section: Introductionmentioning

confidence: 99%

Soft materials based on designed self-assembling peptides: from design to application

Tsutsumi

Mihara

2013

Mol. BioSyst.

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Self-assembling peptides (SAPs) are one of the useful tools to fabricate various nanostructures and resulting higher macrostructures from them based on supramolecular chemistry. Recent continuous studies on SAPs give us much important knowledge, from the design of SAPs to their application as nanomaterials and biomaterials. The process from design to application of SAPs includes steps of optimization in self-assembling properties and functionalization. This review briefly describes general designs of SAPs, control and functionalization methods of nanostructures fabricated from SAPs and recent application examples.

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“…[32][33][34] The use of short peptides at lower concentrations has potential for practical applications due to its facile and inexpensive preparation on a commercial scale. Here, we describe the biomimetic synthesis of silica nanofibers by using self-assembled peptide nanostructures as templates (Fig.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Silica Nanofibers Templated by Self-Assembled Peptide Nanostructures

Tomizaki

Ahn

Imai

2012

Trans. Mat. Res. Soc. Japan

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There is increasing interest in the synthesis of well-organized silica nanostructures using designed peptides as templates. We have demonstrated an approach to synthesize silica nanofibers by sol-gel condensation of tetramethoxysilane as a silica source on the surface of self-assembled peptide nanofibers. Nonapeptide can undergo self-assembly to form peptide nanofibers and was used as templates for silicification under ambient conditions. Peptide nanofibers were stably entrapped within the silica precipitates through templating. The silica morphology and dimensions remained largely intact even after removal of the template by calcination. These findings clearly indicate that the peptide nanoarchitecture allows us to increase diversity in peptide-templated inorganic material synthesis and mimics the natural biomineralization process by means of facile, chemically synthesizable, and controllable self-assembling peptides. This would be an effective approach to produce bulk amounts of inorganic nanostructures for various applications.

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Design, Synthesis, and Characterization of Self-assembled Peptide Nanostructures toward Peptide-directed Biomineralization

Cited by 8 publications

References 14 publications

Biomimetic Alignment of Zinc Oxide Nanoparticles along a Peptide Nanofiber

Biomimetic Alignment of Zinc Oxide Nanoparticles along a Peptide Nanofiber

Soft materials based on designed self-assembling peptides: from design to application

Synthesis of Silica Nanofibers Templated by Self-Assembled Peptide Nanostructures

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