Design, Synthesis and Cytotoxic Activities of Pyrazole‐Perimidine Hybrids

Abstract

The hybrid molecules are one of the powerful tools used in the new drug discovery. In this work, nine perimidine-pyrazole hybrids were designed and synthesized. All structures of the novel compounds were characterized elemental analysis, FTIR, NMR and HRMS. Genotoxic, mutagenic and carcinogenic effects of two of the synthesized compounds were evaluated. The tested compounds could cause chromosomal damage by genotoxic potential and mitotic delay by cytotoxic potential at high concentrations (25-100 μM). Results and Discussion ChemistryIn this study, new hybrid compounds containing perimidine and pyrazole structures were targeted within the scope of synthesis studies. The novel compounds (4 and 5) have been [a] Dr.

MOF-303 as an Effective Adsorbent to Clean CH4: SO2 Capture and Detection

“…The FTIR experiment (Figure S2) displays the absorption bands corresponding to coordinated carboxyl at 1604 and 1385 cm –1 , which confirms the bond between the PZDC linker and the Al­(III) atoms . The bands at 1529, 1476, and 1004 cm –1 are attributed to the pyrazole site for CN, C–C, and N–NH bonds, respectively . The stretching vibrations of Al–O sites are assigned to the bands at 1082 and 630 cm –1 .…”

In Situ Growth of MOF-303 Membranes onto Porous Anodic Aluminum Oxide Substrates for Harvesting Salinity-Gradient Energy

“…Figure c shows the FTIR spectra of the MOF-303 powder, AAO, and MOF-303/AAO membranes. The peaks at 1001, 1478, and 1529 cm –1 correspond to the vibrations of N–NH, C–C, and C–N bonds, respectively, , demonstrating the existence of the pyrazole group. In particular, the peaks at 1386 and 1604 cm –1 indicate the presence of carboxyl coordination in the sample, which can serve as strong evidence for the binding of the organic ligand HPDC 2– to Al 3+ .…”

Fabrication of PA-PEI-MOF303(Al) by Stepwise Impregnation Layer-by-Layer Growth for Highly Efficient Removal of Ammonia

“…The FTIR spectra are shown in Figure 5 a. A peak in the MOF303(Al) spectrum at 3394 cm −1 was assigned to N–H stretching vibrations [ 64 ], peaks at 3146 and 3009 cm −1 were assigned to aromatic C–H stretching vibrations, a peak at 1529 cm −1 was assigned to C=N stretching vibrations, a peak at 1000 cm −1 was assigned to N–NH vibrations [ 65 , 66 ], and peaks at 1393 cm −1 and 1607 cm −1 were assigned to coordination carboxyl groups of –COO–Al [ 67 ]. The MOF303(Al) and PA-PEI-MOF303(Al) FTIR spectra each contained a peak at 1601 cm −1 that was not present in the PA-PEI spectrum.…”

“…Five obvious auto-peaks were found at 986, 1020, 1080, 1220, and 1370 cm −1 . These were assigned to C–O, N–H, and NH 3 absorption [ 65 ]. The cross-peaks at 1370 cm −1 (NH 3 ) and 1220 cm −1 (partial N–H intra-planar wobbling vibrations) changed in opposite directions, indicating that strong hydrogen bonding occurred between NH 3 and the N–H sites on the MOF, i.e., H–N(MOF)···H(NH 3 ) bonds formed [ 82 ].…”