2022
DOI: 10.1063/5.0093814
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Design, synthesis and evaluation in vitro antibacterial activity of new 1,2,3-triazole derivatives

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“…3,4 Synthetically, 1,2,3-triazole ring system is easily constructed via 1,3-dipolar cycloaddition reactions of organic azides with alkynes or activated alkenes under different conditions to give regioselective 1,4-disubstitued-1,2,3-triazole derivatives. [5][6][7][8] Characteristically, 1,2,3-triazole ring system is amide bond isosteres to be resistance the biological degradation, 9 stable towards chemical hydrolysis, oxidative and reductive conditions. 4 Moreover, 1,2,3-triazole ring system can form interactions via hydrogen bonding Vander-Waals forces, π-π stacking interactions and dipole-dipole bonds with a variety of receptors such as enzymes, proteins and nucleic acids.…”
mentioning
confidence: 99%
“…3,4 Synthetically, 1,2,3-triazole ring system is easily constructed via 1,3-dipolar cycloaddition reactions of organic azides with alkynes or activated alkenes under different conditions to give regioselective 1,4-disubstitued-1,2,3-triazole derivatives. [5][6][7][8] Characteristically, 1,2,3-triazole ring system is amide bond isosteres to be resistance the biological degradation, 9 stable towards chemical hydrolysis, oxidative and reductive conditions. 4 Moreover, 1,2,3-triazole ring system can form interactions via hydrogen bonding Vander-Waals forces, π-π stacking interactions and dipole-dipole bonds with a variety of receptors such as enzymes, proteins and nucleic acids.…”
mentioning
confidence: 99%