Design, synthesis, and evaluation of 2,2’-bipyridyl derivatives as bifunctional agents against Alzheimer’s disease

Tan, Ren-Xian; Li, Weihao; Pang, Jia-Min; Zhong, Si-Min; Huang, Xinyi; Deng, Junze; Zhou, Luyi; Wu, Jia‐Qiang; Wang, Xiaoqin

doi:10.1007/s11030-023-10651-5

Cited by 5 publications

(1 citation statement)

References 60 publications

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“…In a recent study by Tan et al [ 114 ], eleven novel 3,3′-diamino-2,2′-bipyridine derivatives were prepared and subsequently tested as potential chelators for AD therapy. The results proved that majority of the derivatives significantly inhibit self-induced aggregation of Aβ 1–42 .…”

Section: Metal Chelators For the Potential Treatment Of Admentioning

confidence: 99%

Targeting Biometals in Alzheimer’s Disease with Metal Chelating Agents Including Coumarin Derivatives

Gucký,

Hamuľaková

2024

CNS Drugs

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Numerous physiological processes happening in the human body, including cerebral development and function, require the participation of biometal ions such as iron, copper, and zinc. Their dyshomeostasis may, however, contribute to the onset of Alzheimer’s disease (AD) and potentially other neurodegenerative diseases. Chelation of biometal ions is therefore a therapeutic strategy against AD. This review provides a survey of natural and synthetic chelating agents that are or could potentially be used to target the metal hypothesis of AD. Since metal dyshomeostasis is not the only pathological aspect of AD, and the nature of this disorder is very complex and multifactiorial, the most efficient therapeutics should target as many neurotoxic factors as possible. Various coumarin derivatives match this description and apart from being able to chelate metal ions, they exhibit the capacity to inhibit cholinesterases (ChEs) and monoamine oxidase B (MAO-B) while also possessing antioxidant, anti-inflammatory, and numerous other beneficial effects. Compounds based on the coumarin scaffold therefore represent a desirable class of anti-AD therapeutics.

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Section: Metal Chelators For the Potential Treatment Of Admentioning

confidence: 99%

Targeting Biometals in Alzheimer’s Disease with Metal Chelating Agents Including Coumarin Derivatives

Gucký,

Hamuľaková

2024

CNS Drugs

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Emodin derivatives as promising multi-aspect intervention agents for amyloid aggregation: molecular docking/dynamics simulation, bioactivities evaluation, and cytoprotection

Shen,

Zhao,

et al. 2023

Mol Divers

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Aminopolycarboxylate zinc(II) complexes with 1,10-phenanthroline and 2,2′-bipyridyl: kinetic studies in the surfactants solutions systems

Malinowski,

Drzeżdżon,

Jacewicz

2023

Reac Kinet Mech Cat

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Aminopolycarboxylate zinc(II) complexes with 1,10-phenanthroline and 2,2′-bipyridyl {[Zn(IDA)(H2O)2], [Zn(IDA)(bipy)(H2O)]·2H2O and [Zn(IDA)(phen)(H2O)]·2H2O} were synthesized. In order to confirm the composition and purity of the synthesized complex compounds, elemental analysis was used. Next, the kinetics of the substitution reaction of two water molecules in the zinc(II) iminodiacetate complex for 1,10-phenanthroline and 2,2′-bipyridyl in two surfactant solvents: CTAB and Triton X-100 were investigated. The kinetic studies were carried out using the stopped flow method. The kinetic research were carried out at 3 different temperatures: 288.15, 293.15 and 298.15 K and at different molar concentrations of the complex compound [Zn(IDA)(H2O)2]: 1 mM; 0.75 mM, 0.5 mM and 0.25 mM and at a constant molar concentration of ligands: i.e. 1,10-phenanthroline and 2,2′-bipyridyl, were 0.05 mM. Changes in absorbance during the kinetic run of the tested reactions were measured at a wavelength of 260 nm. Thanks to the conducted kinetic studies, the order of the reaction was determined, and the observable rate constants of the reaction rates of the substitution of two aqua molecules into the N-donor ligand were determined by the stopped—flow method using the Glint program. In the next step the thermodynamic parameters of complexes: {[Zn(IDA)(H2O)2], [Zn(IDA)(bipy)(H2O)]·2H2O and [Zn(IDA)(phen)(H2O)]·2H2O} in aqueous solutions by use potentiometric titrations were determined. The Hyperquad2018 program was used for determining of stability constants. In addition, the stoichiometry of complexes of zinc(II) with N-heterocyclic ligands in aqueous solutions was determined using the conductometric titrations.

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Design, synthesis, and evaluation of 2,2’-bipyridyl derivatives as bifunctional agents against Alzheimer’s disease

Cited by 5 publications

References 60 publications

Targeting Biometals in Alzheimer’s Disease with Metal Chelating Agents Including Coumarin Derivatives

Targeting Biometals in Alzheimer’s Disease with Metal Chelating Agents Including Coumarin Derivatives

Emodin derivatives as promising multi-aspect intervention agents for amyloid aggregation: molecular docking/dynamics simulation, bioactivities evaluation, and cytoprotection

Aminopolycarboxylate zinc(II) complexes with 1,10-phenanthroline and 2,2′-bipyridyl: kinetic studies in the surfactants solutions systems

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