Design, synthesis, and evaluation of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents

Rawal, Ravindra K.; Tripathi, Renu; Katti, S. B.; Pannecouque, Christophe; Clercq, Erik De

doi:10.1016/j.bmc.2006.12.003

Cited by 175 publications

(97 citation statements)

References 13 publications

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“…The thiazole derivatives are widely used in the field of medicine, industry and in agriculture. The derivatives of thiazole have been reported as fungicides [2][3] , Pesticides 4 , insectides 5 , antibacterial [6][7] , anti-inflammatory 8 , anticonvulsant 9 , antitubercular 10 , antiviral 11 , and anticancer …”

Section: Quick Response Code Doimentioning

confidence: 99%

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2015

IJPSR

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ABSTRACT:The condensation of 2-imino-5 substituted benzylidene-4-thiazolidinone (1) with thiourea (2) in presence of glacial acetic acid to gives 2-substituted imino-7-substituted phenyl-3,7-dihydro-2H-[1,3] thiazolo [5,4-e]-thiazin-5-amine (3). The antifungal activities of the compounds (3a-h) were tested against A.niger and A. flavus. The growth of both fungi A. niger and A. flavus are inhibited to some extent by all the synthesized compounds Hence all are antifungal agents.

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Section: Quick Response Code Doimentioning

confidence: 99%

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2015

IJPSR

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“…[160], [161] While there have been multiple synthestic approaches, there is still considerable scope to develop a more environmentally friendy and efficient approach to this scaffold. [162], [163] Lingampalle et al have developed a rapid entry to 4-thiazolidinones via the N-methylpyridinium tosylate [NMP][Ts] cyclocondensation of amines, aromatic ketones, and mercaptoacetic acid.…”

Section: Crs Yielding Heterocycles With Ring Sulfur and Nitrogen Atomsmentioning

confidence: 99%

Multicomponent Reactions in Ionic Liquids

Otaibi¹,

McCluskey²

2013

Ionic Liquids - New Aspects for the Future

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“…Many effects have been found, including anti-inflammatory and analgesic [15], antitubercular [16], antimicrobial and antifungal [17], antiviral, especially as anti-HIV agents [18], anticancer, antioxidants [19], anticonvulsants [20] and antidiabetic activity [21]. In the present study, some new derivatives of ibuprofen that contain thiazolidine-4-one scaffolds were synthesized in order to obtain compounds with double effect-antioxidant and anti-inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of New 1,3-Thiazolidine-4-one Derivatives of 2-(4-Isobutylphenyl)propionic Acid

et al. 2014

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New thiazolidine-4-one derivatives of 2-(4-isobutylphenyl)propionic acid (ibuprofen) have been synthesized as potential anti-inflammatory drugs. The structure of the new compounds was proved using spectral methods (FR-IR, 1 H-NMR, 13 C-NMR, MS). The in vitro antioxidant potential of the synthesized compounds was evaluated according to the total antioxidant activity, the DPPH and ABTS radical scavenging assays. Reactive oxygen species (ROS) and free radicals are considered to be involved in many pathological events like diabetes mellitus, neurodegenerative diseases, cancer, infections and more recently, in inflammation. It is known that overproduction of free radicals may initiate and amplify the inflammatory process via upregulation of genes involved in the production of proinflammatory cytokines and adhesion molecules. The chemical modulation of acyl hydrazones of ibuprofen 3a-l through cyclization to the corresponding thiazolidine-4-ones 4a-n led to increased antioxidant potential, as all thiazolidine-4-ones were more active than their parent acyl hydrazones and also ibuprofen. The most active compounds are the thiazolidine-4-ones 4e, m, which showed the highest DPPH radical scavenging ability, their activity being comparable with vitamin E.

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Design, synthesis, and evaluation of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents

Cited by 175 publications

References 13 publications

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Multicomponent Reactions in Ionic Liquids

Synthesis and Biological Evaluation of New 1,3-Thiazolidine-4-one Derivatives of 2-(4-Isobutylphenyl)propionic Acid

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