Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death

Tu, Zhi-Shan; Wang, Qi; Sun, Dandan; Dai, Fang; Zhou, Bo

doi:10.1016/j.ejmech.2017.04.008

Cited by 45 publications

(26 citation statements)

References 44 publications

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“…The beneficial effects of curcumin are not only is due to its ability to cross the BBB, but also it has been linked to the activation of NRF2 as well as superoxide dismutase and glutathione peroxidase [21,[121][122][123][124][125][126]. Recent studies have also revealed that curcumin lessened brain edema and oxidative damage by enhancing NRF2 expression and [22,127,128] antioxidant enzymes, i.e., Nqo1, Hmox1 Gclm, and Gclc, as well as down-regulating NF-kB. Additionally, several studies have indicated that curcumin could promote membrane and energy homeostasis and influence synaptic plasticity following TBI [129,130].…”

Section: Current Treatments Of Tbimentioning

confidence: 99%

Traumatic Brain Injury and Blood–Brain Barrier (BBB): Underlying Pathophysiological Mechanisms and the Influence of Cigarette Smoking as a Premorbid Condition

Sivandzade

Alqahtani

Cucullo

2020

IJMS

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Traumatic brain injury (TBI) is among the most pressing global health issues and prevalent causes of cerebrovascular and neurological disorders all over the world. In addition to the brain injury, TBI may also alter the systemic immune response. Thus, TBI patients become vulnerable to infections, have worse neurological outcomes, and exhibit a higher rate of mortality and morbidity. It is well established that brain injury leads to impairments of the blood–brain barrier (BBB) integrity and function, contributing to the loss of neural tissue and affecting the response to neuroprotective drugs. Thus, stabilization/protection of the BBB after TBI could be a promising strategy to limit neuronal inflammation, secondary brain damage, and acute neurodegeneration. Herein, we present a review highlighting the significant post-traumatic effects of TBI on the cerebrovascular system. These include the loss of BBB integrity and selective permeability, impact on BBB transport mechanisms, post-traumatic cerebral edema formation, and significant pathophysiological factors that may further exacerbate post-traumatic BBB dysfunctions. Furthermore, we discuss the post-traumatic impacts of chronic smoking, which has been recently shown to act as a premorbid condition that impairs post-TBI recovery. Indeed, understanding the underlying molecular mechanisms associated with TBI damage is essential to better understand the pathogenesis and progression of post-traumatic secondary brain injury and the development of targeted treatments to improve outcomes and speed up the recovery process. Therapies aimed at restoring/protecting the BBB may reduce the post-traumatic burden of TBI by minimizing the impairment of brain homeostasis and help to restore an optimal microenvironment to support neuronal repair.

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Section: Current Treatments Of Tbimentioning

confidence: 99%

Traumatic Brain Injury and Blood–Brain Barrier (BBB): Underlying Pathophysiological Mechanisms and the Influence of Cigarette Smoking as a Premorbid Condition

Sivandzade

Alqahtani

Cucullo

2020

IJMS

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“…Its anti‐tumour effect has been observed in several cultural cells and animal systems through inducing apoptosis by elevating pro‐apoptotic elements including Bax, cytosolic cytochrome C, activated‐caspase‐3, and activated‐caspase‐9, promoting S phase arrest, suppressing NF‐κB signalling and so forth. Meanwhile, curcumin (CUR) as a multi‐target agent in the spice turmeric exhibited anti‐inflammatory, anti‐proliferative, anti‐oxidant, pro‐apoptotic and so forth effects against a variety of cancer models. It also enhanced the efficacy of some chemotherapy drugs by improving their pharmacokinetics, inducing apoptosis and so on.…”

Section: Introductionmentioning

confidence: 99%

Curcumin enhances the anti‐cancer effects of Paris Saponin II in lung cancer cells

et al. 2018

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“…In another study, natural curcumin-directed Nrf2 activators were synthesized and evaluated for their cytoprotective effects. 110 The catechol-type curcumin analog (compound 34) was selected as one of the most promising compounds due to high stability and cytoprotective activity against the tert -butyl hydroperoxide-induced death of HepG2 cells. According to mechanistic studies, this activity is mediated by the activation of the Nrf2 signaling pathway in the Michael acceptor- and catechol-dependent manners.…”

Section: Nrf2 Modulators For Cancer Prevention and Therapymentioning

confidence: 99%

Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review

Sova

Saso²

2018

DDDT

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A major cell defense mechanism against oxidative and xenobiotic stress is mediated by the Nrf2/Keap1 signaling pathway. The Nrf2/Keap1 pathway regulates gene expression of many cytoprotective and detoxifying enzymes, thus playing a pivotal role in maintaining redox cellular homeostasis. Many diseases including cancer have been closely related to impaired Nrf2 activity. Targeting Nrf2 and modulating its activity represents a novel modern strategy for cancer chemoprevention and therapy. In this review, different design strategies used for the development of Nrf2 modulators are described in detail. Moreover, the main focus is on important and recently developed Nrf2 activators and inhibitors, their in vitro and in vivo studies, and their potential use as chemopreventive agents and/or cancer therapeutics.

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Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death

Cited by 45 publications

References 44 publications

Traumatic Brain Injury and Blood–Brain Barrier (BBB): Underlying Pathophysiological Mechanisms and the Influence of Cigarette Smoking as a Premorbid Condition

Traumatic Brain Injury and Blood–Brain Barrier (BBB): Underlying Pathophysiological Mechanisms and the Influence of Cigarette Smoking as a Premorbid Condition

Curcumin enhances the anti‐cancer effects of Paris Saponin II in lung cancer cells

Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review

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